Correlation Between Total Imaging Burden of Cerebral Small Vessel Disease and Distribution of Collateral Disease Syndrome Types in Traditional Chinese Medicine

Corresponding author: QIU Weiwen, weiwenq@hotmail.com

DOI: 10.12201/bmr.202606.00079

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  Abstract: Objective To explore the relationship between the total imaging burden of Cerebral Small Vessel Disease (CSVD) and the distribution of Traditional Chinese Medicine (TCM) collateral disease syndrome types.Methods A total of 149 CSVD patients treated in the outpatient and inpatient departments of Lishui TCM Hospital Affiliated to Zhejiang Chinese Medical University from October 2024 to October 2025 were selected.The total CSVD burden was assessed for all enrolled subjects, including Lacunar Infarcts (LI), White Matter Hyperintensities (WMH), Cerebral Microbleeds (CMB), and Perivascular Spaces (PVS). Concurrently, TCM collateral disease syndrome differentiation was completed, categorizing patients into four syndrome types: brain collateral impoverishment (BCI) , brain collateral stasis (BCS) , brain collateral constraint (BCC),and Brain Collateral Occlusion(BCO).Results The distribution of the four TCM collateral disease syndrome types differed significantly among CSVD burden groups of varying severity (P<0.05). As the total CSVD imaging burden increased, the predominant TCM syndrome type evolved from BCI and BCS towards BCC and BCO. Patients with BCO and BCC types had significantly higher Fazekas grades for WMH and higher counts of basal ganglia PVS compared to those with BCI and BCS types. The BCS types had the highest incidence of CMB, while the BCO types had the highest incidence of LI (both P<0.05).Conclusion A significant correlation exists between the total imaging burden of CSVD and the distribution of TCM collateral disease syndrome types. Higher total imaging burden scores are associated with a tendency towards the more complex syndrome types of BCC and BCO. This total imaging burden score may provide imaging-based evidence to inform TCM collateral disease syndrome differentiation.

  Key words: Cerebral small vessel disease; Total imaging burden; Traditional chinese medicine collateral disease; Syndrome differentiation

  Submit time: 29 June 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-04-12	10.12201/bmr.202606.00079V1	Download

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