通讯作者: 邱伟文, weiwenq@hotmail.com

DOI：10.12201/bmr.202606.00079

Correlation Between Total Imaging Burden of Cerebral Small Vessel Disease and Distribution of Collateral Disease Syndrome Types in Traditional Chinese Medicine

• 摘要：目的:探讨脑小血管病(CSVD)影像学总负荷与中医络病证型分布之间的关系。方法:选取2024年10月至2025年10月浙江中医药大学附属丽水中医院门诊和住院部收治的CSVD患者149例。对所有入组研究对象进行CSVD总负荷评估,包括腔隙(LI)、脑白质高信号(WMH)、脑微出血(CMB)、血管周围间隙(PVS)。同时完成中医络病辨证分型,包括脑络失荣、脑络瘀阻、脑络绌急、脑络瘀塞4种证型。结果:4种中医络病证型在不同严重程度的CSVD评分组别中分布具有差异性(P < 0.05)。随着CSVD影像学总负荷加重,中医证型呈现由脑络失荣、脑络瘀阻为主向脑络绌急、脑络瘀塞为主演变的趋势。脑络瘀塞型和脑络绌急型患者的白质高信号Fazekas分级及基底节PVS数量均显著高于脑络失荣型和脑络瘀阻型患者,脑络瘀阻型的CMB发生率最高,脑络瘀塞型的LI发生率最高(P均< 0.05)。结论:CSVD影像学总负荷与中医络病证型分布存在显著相关性,影像学总负荷评分越高,证型越趋向于脑络绌急、脑络瘀塞的复杂证型。这种影像学评分或可为中医络病辨证提供影像学参考。

  关键词： 脑小血管病; 影像学总负荷; 中医络病; 辨证分型

   

  Abstract: Objective To explore the relationship between the total imaging burden of Cerebral Small Vessel Disease (CSVD) and the distribution of Traditional Chinese Medicine (TCM) collateral disease syndrome types.Methods A total of 149 CSVD patients treated in the outpatient and inpatient departments of Lishui TCM Hospital Affiliated to Zhejiang Chinese Medical University from October 2024 to October 2025 were selected.The total CSVD burden was assessed for all enrolled subjects, including Lacunar Infarcts (LI), White Matter Hyperintensities (WMH), Cerebral Microbleeds (CMB), and Perivascular Spaces (PVS). Concurrently, TCM collateral disease syndrome differentiation was completed, categorizing patients into four syndrome types: brain collateral impoverishment (BCI) , brain collateral stasis (BCS) , brain collateral constraint (BCC),and Brain Collateral Occlusion(BCO).Results The distribution of the four TCM collateral disease syndrome types differed significantly among CSVD burden groups of varying severity (P<0.05). As the total CSVD imaging burden increased, the predominant TCM syndrome type evolved from BCI and BCS towards BCC and BCO. Patients with BCO and BCC types had significantly higher Fazekas grades for WMH and higher counts of basal ganglia PVS compared to those with BCI and BCS types. The BCS types had the highest incidence of CMB, while the BCO types had the highest incidence of LI (both P<0.05).Conclusion A significant correlation exists between the total imaging burden of CSVD and the distribution of TCM collateral disease syndrome types. Higher total imaging burden scores are associated with a tendency towards the more complex syndrome types of BCC and BCO. This total imaging burden score may provide imaging-based evidence to inform TCM collateral disease syndrome differentiation.

  Key words: Cerebral small vessel disease; Total imaging burden; Traditional chinese medicine collateral disease; Syndrome differentiation

  提交时间：2026-06-29

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 张二利, 何兰兰, 李丹阳, 沈立, 吴钟华, 张军, 叶永强. 基于脑小血管病影像学总负荷的急性脑梗死患者住院时间延长列线图模型构建与验证. 2025. doi: 10.12201/bmr.202501.00008

  占剑虎, 邱伟文, 蓝海源, 王华强. 脑白质高信号严重程度与络病学证型分布研究. 2024. doi: 10.12201/bmr.202411.00015

  王奕程, 钟远鸣, 付小鹏. 基于“气逆挟脊”探讨脊髓型颈椎病的中医证治. 2025. doi: 10.12201/bmr.202512.00028

  章涛. VCIND与认知正常脑血管病患者脑血管形态学及血清学相关指标差异分析. 2025. doi: 10.12201/bmr.202501.00031

  梁乐然, 阎誉豪, 唐跃豪, 练洢彤, 徐倩, 杨猛, 伍家亨, 陈振虎, 刘秀峰. 基于知识图谱和大语言模型的中医药治疗帕金森病智能问答研究. 2026. doi: 10.12201/bmr.202604.00033

  邓丽华, 刘晓鹰, 徐克菲. 贝利尤单抗联合中药辨证方治疗狼疮性肾炎患儿1例. 2024. doi: 10.12201/bmr.202409.00041

  沈榕, 李家宇, 盛博洋, 钟俐芹, 荆晓朔, 晏峻峰. 基于机器学习的中医肺癌辨证智能模型的构建研究. 2026. doi: 10.12201/bmr.202604.00093

  赵萍萍, 孟立锋. 基于“年龄分层”探讨慢性肾脏病的中医治则. 2026. doi: 10.12201/bmr.202603.00100

  李聪颖, 周晓辉. 脑小血管病相关认知障碍的研究进展. 2026. doi: 10.12201/bmr.202602.00091

  陈文会. 盆腔炎性疾病后遗症中西医发病机制及治疗研究进展. 2026. doi: 10.12201/bmr.202602.00059

• 序号	提交日期	编号	操作
  1	2026-04-12	10.12201/bmr.202606.00079V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论