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DOI: 10.12201/bmr.202606.00050

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  Abstract: Paget disease of the vulva (PDV)? is a rare malignant tumor of the vulva characterized by a low incidence and atypical clinical symptoms, leading to a high rate of clinical misdiagnosis and missed diagnosis. This article retrospectively analyzed the clinical data of two cases of PDV? treated in our hospital. Case 1? was admitted for surgery due to an ovarian thecoma, and a concurrent PDV was confirmed by intraoperative vulvar biopsy. Case 2? presented with intractable vulvar pruritus accompanied by a local mass, and the diagnosis was definitively established via pathological examination following excision of the lesion. Based on the clinical features, diagnostic and therapeutic processes, and follow-up outcomes of these two patients—combined with a review of relevant literature—we summarized the key points for clinical diagnosis, treatment principles, and precautions for PDV. This study aims to provide a reference for the early recognition and standardized diagnosis and treatment of this disease.

  Key words: Paget disease of the vulva; Vulvar lesions; Pathological biopsy; Immunohistochemistry; Case report

  Submit time: 14 June 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-05-24	10.12201/bmr.202606.00050V1	Download

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