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Corresponding author: Liulanying, balindaliu@163.com

DOI: 10.12201/bmr.202605.00066

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  Abstract: Post-stroke depression (PSD) is a common neuropsychiatric complication in stroke patients during rehabilitation, which seriously hinders neurological recovery and elevates mortality. Due to the influences of cognition, culture and other factors, early identification and intervention are still insufficient in clinical practice. Western medicine mainly interprets the pathogenesis of PSD from the dual hypotheses of endogenous and reactive mechanisms, with diagnosis based on DSM-5 criteria and rehabilitation focusing on neuromodulation and cognitive-psychological interventions. Traditional Chinese Medicine (TCM) categorizes PSD as stroke complicated with depression syndrome, characterized by root deficiency and branch excess, though syndrome differentiation remains inconsistent. Acupuncture, five-tone therapy and tuina are commonly used TCM approaches.Integrated Western and TCM rehabilitation shows synergistic effects and has become a promising direction for PSD management. This paper reviews the research progress of PSD in terms of etiology, pathogenesis, diagnostic criteria, rehabilitation methods and integrated therapy, so as to provide references for clinical diagnosis, treatment and rehabilitation optimization.

  Key words: Post-stroke depression; Integrated rehabilitation of Traditional Chinese Medicine and Western Medicine; Etiology and pathogenesis; Diagnostic criteria; Rehabilitation technology.

  Submit time: 18 May 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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• ID	Submit time	Number	Download
  1	2026-04-04	10.12201/bmr.202605.00066V1	Download

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