The Dual Role of SIRT2 in Inflammatory Bowel Disease.

Corresponding author: CHEN Guiquan▲, chenguiquan1973@126.com

DOI: 10.12201/bmr.202604.00106

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  Abstract: Inflammatory bowel disease (IBD) is a chronic intestinal disorder triggered by multiple factors including genetics, immunity, and gut microbiota dysbiosis, with current treatments having certain limitations. Silent information regulator 2 (SIRT2), as a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, exhibits a dual role in IBD characterized by both protective and damaging effects. In terms of protective effects, SIRT2 alleviates intestinal damage by suppressing excessive immune inflammation, regulating macrophage polarization, maintaining regulatory T cell stability, and preserving intestinal epithelial barrier integrity. Conversely, regarding detrimental effects, SIRT2 can inhibit immune cell function, promote inflammation through metabolic reprogramming, and disrupt the epithelial barrier. This paradoxical nature is closely associated with differences in intervention approaches, cell-type specificity, dynamic disease stages, and the complexity of molecular networks. Therefore, future SIRT2-targeted therapies may shift toward precise regulation by selecting appropriate intervention methods tailored to specific cell types and disease stages, offering novel strategies for IBD treatment.

  Key words: SIRT2; inflammatory bowel disease; dual role; immune regulation; intestinal epithelial barrier; targeted therapy.

  Submit time: 13 April 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-03-16	10.12201/bmr.202604.00106V1	Download

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