A Brief Discussion on Zhang Jingyues Theory of Blood Depletion and Chemotherapy-Induced Menopause
Gan Lunling1,YI Liang Jie2,Tan Siqi1

Corresponding author: yiliangjie, liangjie20210426@163.com

DOI: 10.12201/bmr.202604.00053

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  Abstract: Based on Zhang Jingyues theory of Xueku ,this article explores its correlation with the pathogenesis of chemotherapy-induced menopause in traditional Chinese medicine. Chemotherapeutic toxins directly damage the liver and kidneys, consuming and depleting essence and blood, leading to kidney essence depletion and premature exhaustion of Tian Gui (reproductive essence). The core pathogenesis of simultaneous depletion of essence and blood aligns closely with the concept of source exhaustion and no blood to flow in blood depletion. By integrating Chinese and Western medical perspectives, this study reveals the correspondence between blood depletion and diminished ovarian reserve, as well as endocrine-immune network dysregulation. The treatment approach emphasizes replenishing essence and blood, strengthening the spleen and kidneys as the core, highlighting the balance of yin and yang and treatment based on syndrome differentiation. Formulas such as Zuogui Wan and Yougui Wan are selected, employing the method of unblocking through tonification to restore the normal function of the uterus in storing and discharging blood. This provides a theoretical basis and practical insights for the clinical diagnosis and treatment of chemotherapy-induced menopause.
  Keywords: Zhang Jingyue; Xueku; Post-chemotherapy Menopause;

  Key words: ; ; 

  Submit time: 8 April 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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