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Corresponding author: wangying, wangying2012@qq.com

DOI: 10.12201/bmr.202512.00068

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  Abstract: Objective:This study aimed to evaluate the efficacy of acupuncture at Zusanli (ST36) combined with Zhongwan (CV12), Qihai (CV6), and Tianshu (ST25) in alleviating myelosuppression following chemotherapy in breast cancer patients. Methods:Thirty-eight postoperative chemotherapy patients admitted between March and June 2025 were enrolled in a self-controlled trial. The first chemotherapy cycle served as the control group, where recombinant human granulocyte colony-stimulating factor (rhG-CSF) was administered upon myelosuppression. The second cycle constituted the experimental group, receiving acupuncture at the above points in addition to the control treatment, with a one-week washout period between cycles. Efficacy was assessed by monitoring blood counts and total rhG-CSF usage. Results: the experimental group had significantly higher counts of white blood cells, neutrophils, red blood cells, hemoglobin, and platelets at multiple time points (all P < 0.05), along with a significantly lower total rhG-CSF dose (P < 0.05). conclusion:Acupuncture at Zusanli combined with Zhongwan, Qihai, and Tianshu can mitigate chemotherapy-induced myelosuppression, reduce reliance on rhG-CSF, and promote hematological recovery. This safe and practical acupuncture regimen is worthy of broader application.

  Key words: Breast Cancer; Chemotherapy; Acupuncture; Myelosuppression

  Submit time: 24 December 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2025-11-05	10.12201/bmr.202512.00068V1	Download

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