通讯作者: 易良杰, liangjie20210426@163.com

DOI：10.12201/bmr.202604.00053

A Brief Discussion on Zhang Jingyues Theory of Blood Depletion and Chemotherapy-Induced Menopause
Gan Lunling1,YI Liang Jie2,Tan Siqi1

• 摘要：本文基于张景岳“血枯”理论,探讨其与化疗后闭经的中医病机关联。化疗药毒直损肝肾,耗伤精血,致肾精亏竭、天癸早竭,其精血同亏之核心病机与血枯之源泉枯竭,无血可下高度契合。通过中西互参,揭示了血枯与卵巢储备功能下降及内分泌-免疫网络紊乱的对应关系。治疗上提出以“填补精血、培补脾肾”为核心,强调阴阳相济、辨证论治,方选左归丸、右归丸等,以“寓通于补”之法恢复胞宫蓄溢之常,为临床辨治化疗后闭经提供了理论依据与实用思路。

  关键词： 张景岳; 血枯; 化疗后闭经

   

  Abstract: Based on Zhang Jingyues theory of Xueku ,this article explores its correlation with the pathogenesis of chemotherapy-induced menopause in traditional Chinese medicine. Chemotherapeutic toxins directly damage the liver and kidneys, consuming and depleting essence and blood, leading to kidney essence depletion and premature exhaustion of Tian Gui (reproductive essence). The core pathogenesis of simultaneous depletion of essence and blood aligns closely with the concept of source exhaustion and no blood to flow in blood depletion. By integrating Chinese and Western medical perspectives, this study reveals the correspondence between blood depletion and diminished ovarian reserve, as well as endocrine-immune network dysregulation. The treatment approach emphasizes replenishing essence and blood, strengthening the spleen and kidneys as the core, highlighting the balance of yin and yang and treatment based on syndrome differentiation. Formulas such as Zuogui Wan and Yougui Wan are selected, employing the method of unblocking through tonification to restore the normal function of the uterus in storing and discharging blood. This provides a theoretical basis and practical insights for the clinical diagnosis and treatment of chemotherapy-induced menopause.
  Keywords: Zhang Jingyue; Xueku; Post-chemotherapy Menopause;

  Key words: ; ; 

  提交时间：2026-04-08

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2026-02-28	10.12201/bmr.202604.00053V1	下载

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