Based on the theory of Mu Yu DA Zhi and the Gut-Brain-Liver Axis, a Discussion on the Etiology, Pathogenesis and Differentiation and Treatment of Irritable Bowel Syndrome

Corresponding author: Duan Xiaorong

DOI: 10.12201/bmr.202604.00031

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  Abstract: Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder with a complex pathogenesis involving abnormal brain-gut interaction, disrupted intestinal flora, imbalanced bile acid metabolism, increased visceral sensitivity, and immune inflammatory activation. The Mu Yu DA Zhi theory reveals the pathological state of liver qi stagnation and its treatment principle of reaching out and regulating; the gut-brain-liver axis as a bidirectional regulatory network connecting the gut, the brain, and the liver, is closely related to the occurrence and development of IBS. This article aims to explore the intrinsic connection between the Mu Yu DA Zhi theory and the gut-brain-liver axis mechanism in IBS, providing new ideas and theoretical basis for clinical prevention and treatment of IBS.

  Key words: Irritable Bowel Syndrome; Mu Yu DA Zhi; Intestine-Brain-Liver Axis; Etiology and Pathogenesis; Syndrome Differentiation and Treatment

  Submit time: 5 April 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-03-22	10.12201/bmr.202604.00031V1	Download

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