The Role of Histone Lactylation in Neurological Disorders: Progress and Challenges

Corresponding author: HE Xiaoying, 102050228@qq.com

DOI: 10.12201/bmr.202603.00028

•  

  Abstract: Since its discovery in 2019, histone lactylation has emerged as a research hotspot in neurological disorders. This review systematically summarizes recent advances in its roles across neurodegenerative diseases (such as Alzheimer‘s disease and Parkinson’s disease), acute brain injuries (including ischemic stroke and subarachnoid hemorrhage), as well as neurodevelopmental and metabolism-related disorders. Based on this, we further explore the multidimensional regulatory patterns and common mechanisms of lactylation modifications and discuss the potential of targeting lactylation pathways as therapeutic strategies.

  Key words: Histone lactylation; post-translational modifications; Nervous System Diseases; Neuroinflammation

  Submit time: 10 March 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• shenzhouji, guofei. Research progress of histone modification and DNA methylation in diabetes nephropathy. 2024. doi: 10.12201/bmr.202407.00011

  Gao Xiang. Research Progress on the Association between the Calsyntenin Family and Diseases. 2026. doi: 10.12201/bmr.202604.00160

  WangJing. Research progress of Xiangsha Liujunzi Tang in digestive system diseases. 2025. doi: 10.12201/bmr.202503.00015

  chengjiawei, lijinhu, siwenshuo, liutao, niuguoqi. . 2025. doi: 10.12201/bmr.202504.00061

  lubo, LvYingYing, ChenYuYan. . 2025. doi: 10.12201/bmr.202506.00054

  FengPengya, ZhangYangyang, LiHonglei, YangJumeng, JinKe, Li Enyao. . 2026. doi: 10.12201/bmr.202603.00031

  . 2025. doi: 10.12201/bmr.202502.00001

  LIU Ruyang, ZHANG Guopeng, SUN Hongwei, FANG Zhensheng. Research progress of IL-37 in respiratory diseases. 2025. doi: 10.12201/bmr.202501.00038

  Jiyunxi. Research progress on the role of protein ubiquitination in the occurrence and development of gastric cancer. 2026. doi: 10.12201/bmr.202601.00012

  Xuzhiwei, Wuzhenbin. Research progress on sarcopenia and imaging evaluation related to musculoskeletal system diseases. 2026. doi: 10.12201/bmr.202601.00038

• ID	Submit time	Number	Download
  1	2026-02-13	10.12201/bmr.202603.00028V1	Download

• Public  Anonymous  To author only Submit Comments