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DOI: 10.12201/bmr.202601.00088

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  Abstract: ABSTRACT：Objective This study aimed to systematically investigate the chemical constituents and potential mechanism of the characteristic herb pair Juglandis Semen fried with Psoraleae Fructus from the Menghe Medical School in treating kidney-yang deficiency type depression, based on UPLC-Q-Orbitrap-MS technology and network pharmacology. Method The chemical components of the extract from Juglandis Semen fried with Psoraleae Fructus were identified by UPLC-Q-Orbitrap-MS. Active components and their potential targets were screened using network pharmacology methods. A component-target-pathway network was constructed, and the biological processes and signaling pathways involved in its antidepressant effects were explored through GO and KEGG enrichment analysis.Results A total of 49 chemical components were identified from Juglandis Semen fried with Psoraleae Fructus, including 14 confirmed compounds such as psoralen, isopsoralen, and bavachinin. Network pharmacology screening identified 30 active components, 117 intersection targets, and 20 key pathways, involving neuroactive ligand-receptor interaction, cAMP signaling pathway, serotonergic synapse, PI3K-Akt signaling pathway, among others. Key active components included neobavaisoflavone, psoralen, isopsoralen, etc.Conclusion Juglandis Semen fried with Psoraleae Fructus may exert therapeutic effects on kidney-yang deficiency type depression through multi-component, multi-target, and multi-pathway synergistic actions, potentially involving mechanisms such as neurotransmitter regulation, anti-inflammation, anti-oxidation, and neuroprotection. This study provides a theoretical basis for subsequent experimental validation and clinical application.

  Key words: Menghe Medical School; JUGLANDIS SEMEN; PSORALEAE FRUCTUS; Network Pharmacology; Depression; UPLC-Q-Exactive Orbitrap-MS

  Submit time: 29 January 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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• CHEN Yangbo. . 2025. doi: 10.12201/bmr.202511.00088

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