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Corresponding author: CHEN Yangbo, jiangjiahui1023@163.com

DOI: 10.12201/bmr.202511.00088

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  Abstract: Objective This study aims to systematically elucidate the potential mechanism of Buzhong Yiqi formula in intervening Sarcopenia through network pharmacology and molecular docking techniques.Methods Active components of the 7 medicinal herbs in Buzhong Yiqi formula were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP);targets of these active components were obtained via TCMSP and the Swiss Target Prediction database;Sarcopenia-related disease targets were extracted from disease database;a Venn diagram was plotted using the online tool Venny 2.1.0 to identify the intersection between the targets of the active components in the Chinese herbal compound and the disease targets;the intersecting targets were imported into the STRING database to construct a protein-protein interaction(PPI) network,and furthermore,Cytoscape 3.10.3 software was used to draw the drug-component-target network diagram and the PPI network diagram,respectively;on this basis,Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were conducted using the Metascape platform to reveal the biological processes and signaling pathway mechanisms;finally,Autodock Vina 1.5.6 was used for molecular docking verification between core components and key targets,and Pymol 3.0.3 was employed to visualize the results.Results 182 active components and 1139 component targets of Buzhong Yiqi formula were retrieved,along with 415 Sarcopenia-related disease targets,resulting in 62 intersecting targets.Among these,5 main active components were screened out,including quercetin,kaempferol,naringenin,isotrifoliol, and isorhamnetin,and 6 core targets were identified,namely Protein kinase B1(AKT1),Tumor Necrosis Factor(TNF),Tumor Protein p53(TP53),Interleukin 6(IL6),Estrogen Receptor α(ESR1),and Interleukin 1beta(IL1β),which are involved in signaling pathways such as the TNF signaling pathway,insulin resistance,and the adipocytokine signaling pathway;molecular docking analysis showed that the core active components of Buzhong Yiqi formula exhibited strong binding activity and stability with the key targets of Sarcopenia.Conclusion Buzhong Yiqi formula can exert a potential therapeutic effect on Sarcopenia through multiple active components,action targets,and biological pathways.

  Key words: ; ; ; 

  Submit time: 27 November 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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