Experience in Staged Treatment of Lung Cancer Treatment–Related Palpitations Based on the Theory of “Deficiency of Collaterals with Toxin Accumulation”

DOI: 10.12201/bmr.202601.00067

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  Abstract: Lung cancer is one of the malignant tumors with the highest incidence and mortality rates in China. Although chemotherapy, radiotherapy, targeted therapy, and immunotherapy have significantly improved therapeutic outcomes, they are also associated with cardiovascular toxicity. Palpitations are among the common early manifestations and frequent subjective complaints in patients receiving lung cancer treatment.In response to lung cancer treatment–related palpitations, Professor Shu Qijin, based on the theory of Deficiency of Collaterals with Toxin Accumulation, proposes that the core Traditional Chinese Medicine pathogenesis involves depletion of qi and yin, deficiency of the heart collaterals, accumulation of stasis and toxin, and, in advanced stages, impairment of yang following yin deficiency. According to the dynamic evolution of the disease, a staged treatment strategy is applied throughout the clinical course.In the initial stage, characterized mainly by depletion of qi and yin and deficiency of the heart collaterals, treatment focuses on replenishing qi and nourishing yin to restore the heart collaterals, using a modified Shengmai San. In the progressive stage, where stasis and toxin gradually accumulate, treatment emphasizes removing stasis and resolving toxin while avoiding damage to healthy qi, with a modified Xuefu Zhuyu Tang. In the terminal stage, when yin deficiency further affects yang, therapy aims to warm yang and promote diuresis to protect the fundamental vitality, using a modified Zhenwu Tang.Clinical practice requires strict adherence to the underlying pathogenesis, with flexible prescription adjustments according to individual syndromes to ensure precise correspondence between treatment and pattern differentiation. One representative case is presented to illustrate this approach.

  Key words: Lung cancer; Palpitations; Deficiency of collaterals with toxin accumulation; Staged treatment; Renowned physician’s experience

  Submit time: 26 January 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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