通讯作者: 罗周青, luozhouqinghz@163.com

DOI：10.12201/bmr.202601.00067

Experience in Staged Treatment of Lung Cancer Treatment–Related Palpitations Based on the Theory of “Deficiency of Collaterals with Toxin Accumulation”

• 摘要：肺癌是我国发病率及死亡率均居前列的恶性肿瘤之一。放化疗、靶向免疫等治疗对肺癌虽有疗效,但也引发心血管相关毒性。心悸就是其早期表现及患者常见主诉之一。针对肺癌治疗相关心悸,舒琦瑾教授基于“络虚毒结”理论,指出“气阴损耗、心络亏虚,瘀毒蕴结,阴损及阳”的中医病机,遵循病机演变规律以三期辨治体系贯穿始终。初期以气阴损耗、心络亏虚为主,益气养阴而充盈心络,方选生脉散加减；进展期多瘀毒内生,化瘀解毒而谨防伤正,方选血府逐瘀汤加减；终末期阴损及阳,当温阳利水以顾根本,方选真武汤加减。临证需谨守病机,随证加减,药证相应。现附验案1则。

  关键词： 肺癌; 心悸; 络虚毒结; 分期辨治; 名医经验

   

  Abstract: Lung cancer is one of the malignant tumors with the highest incidence and mortality rates in China. Although chemotherapy, radiotherapy, targeted therapy, and immunotherapy have significantly improved therapeutic outcomes, they are also associated with cardiovascular toxicity. Palpitations are among the common early manifestations and frequent subjective complaints in patients receiving lung cancer treatment.In response to lung cancer treatment–related palpitations, Professor Shu Qijin, based on the theory of Deficiency of Collaterals with Toxin Accumulation, proposes that the core Traditional Chinese Medicine pathogenesis involves depletion of qi and yin, deficiency of the heart collaterals, accumulation of stasis and toxin, and, in advanced stages, impairment of yang following yin deficiency. According to the dynamic evolution of the disease, a staged treatment strategy is applied throughout the clinical course.In the initial stage, characterized mainly by depletion of qi and yin and deficiency of the heart collaterals, treatment focuses on replenishing qi and nourishing yin to restore the heart collaterals, using a modified Shengmai San. In the progressive stage, where stasis and toxin gradually accumulate, treatment emphasizes removing stasis and resolving toxin while avoiding damage to healthy qi, with a modified Xuefu Zhuyu Tang. In the terminal stage, when yin deficiency further affects yang, therapy aims to warm yang and promote diuresis to protect the fundamental vitality, using a modified Zhenwu Tang.Clinical practice requires strict adherence to the underlying pathogenesis, with flexible prescription adjustments according to individual syndromes to ensure precise correspondence between treatment and pattern differentiation. One representative case is presented to illustrate this approach.

  Key words: Lung cancer; Palpitations; Deficiency of collaterals with toxin accumulation; Staged treatment; Renowned physician’s experience

  提交时间：2026-01-26

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-12-29	10.12201/bmr.202601.00067V1	下载

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