Molecular Mechanisms and Research Progress of m⁶A Methylation in Regulating Diabetic Wound Healing

Corresponding author: Hongyun Lu, luhongyun@jnu.edu.cn

DOI: 10.12201/bmr.202512.00084

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  Abstract: N⁶-methyladenosine (m⁶A) methylation is one of the most prevalent, dynamic, and reversible internal modifications of messenger RNA (mRNA) in higher eukaryotes. Accumulating evidence suggests a close association between m⁶A modification and the development and progression of diabetes mellitus (DM) and its complications. Chronic diabetic wounds represent a common and severe complication of DM, serving as a major cause of amputation and even mortality in affected patients. Recent studies have demonstrated that aberrant m⁶A methylation may mediate various pathological processes and play a regulatory role in diabetic wound healing. This review summarizes the functions of m⁶A methylation during diabetic wound healing and systematically elucidates the underlying molecular mechanisms. The aim of this study is to provide a scientific basis for the development of novel therapeutic strategies and intervention targets for the treatment of diabetic cutaneous wounds.

  Key words: Diabetes Mellitus; Diabetic Wound; N< sup> 6< /sup> -Methyladenosine

  Submit time: 13 January 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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