Analysis of the association between the cardiometabolic index and diabetes in the elderly based on NHANES

Corresponding author: fuli, 23572515@qq.com

DOI: 10.12201/bmr.202512.00023

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  Abstract: Abstract Objective Investigating the Relationship between the Cardiometabolic Index and Diabetes in the Elderly. Methods Based on data from seven cycles (2005–2018) of the National Health and Nutrition Examination Survey (NHANES), a cross-sectional study was conducted involving 3,769 participants. Participants were divided into two groups according to diabetes status. Logistic regression was used to analyze the association between CMI and diabetes, supplemented by subgroup analysis, interaction tests, and ROC curve analysis. Results The overall prevalence of diabetes was 35.1% (1323/3769). The median CMI in the total population was 0.57 (0.35, 0.94). The CMI in the diabetes group was 0.72 (0.44, 1.12), significantly higher than that in the control group 0.49 (0.30, 0.83). After adjusting for multiple confounding factors, elevated CMI was independently associated with an increased risk of diabetes in the elderly (OR = 1.504, 95% CI: 1.328–1.703, P < 0.0001). Subgroup analysis and Bonferroni correction revealed a significant interaction between CMI and diabetes only in the hypertension subgroup (P for interaction = 0.0011 < 0.0038). Conclusion CMI is positively associated with the risk of diabetes in the elderly. Controlling CMI levels may help reduce the risk of diabetes in the elderly. Key words ?Diabetes Cardiometabolic Index Cross-Sectional Study NHANE

  Key words: Diabetes; Cardiometabolic Index; Cross-Sectional; Study? NHANES

  Submit time: 10 December 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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