通讯作者: 李芳梅, 393774424@qq.com

DOI：10.12201/bmr.202509.00055

Based on data mining from the blood stasis and heat treatment of psoriasis vulgaris drug rules

• 摘要：目的:探索瘀热互结证寻常型银屑病的中医用药规律。方法:搜索建库——通过检索知网、万方、维普三大中文数据库中有关瘀热互结证寻常型银屑病的相关文献,筛选后将处方中药数据录入Microsoft Excel 2016中进行频数统计,分析中药的频次、四气、五味及归经,再利用IBM SPSS Modeler 18.1、IBM SPSS Statistics 26.0对数据进行关联规则分析和聚类分析,探索方剂组方特色、用药规律。结果: 通过对属瘀热互结证的寻常型银屑病的临床文献进行检索并整理,最终纳入符合标准的文献38篇,共涉及38首方剂,121味中药,其中高频药物(≥10次) 共14味,以地黄最常见,药性以寒、微寒居多,药味以苦、甘为主,归经中肝经占比最高；高频药物聚类分析可分为5类,关联规则分析中支持度最高的药对为白鲜皮—白花蛇舌草。结论:通过分析瘀热互结证寻常型银屑病,其治疗主要以清热解毒,活血祛瘀为主,兼以健脾燥湿、益气补血。

  关键词： 瘀热互结; 寻常型银屑病; 用药规律; 数据挖掘; 脾胃湿热

   

  Abstract: Objective: To explore the rules of traditional Chinese medicine (TCM) for psoriasis vulgaris with stasis and heat intertwined. Methods: Search and build a database——By searching the relevant literature on stasis and heat interjunction psoriasis vulgaris in the three major Chinese databases of CNKI, Wanfang and VIP, the prescribed Chinese medicine data were entered into Microsoft Excel 2016 for frequency statistics, the frequency, four qi, five flavors and attribution of Chinese medicine were analyzed, and then IBM SPSS Modeler 18.1 and IBM SPSS Statistics 26.0 were used to perform association rule analysis and cluster analysis of the data. Explore the characteristics of prescription composition and medication rules. Results: Through the search and sorting of the clinical literature of psoriasis vulgaris belonging to the stasis and heat syndrome, 38 articles that met the criteria were finally included, involving 38 prescriptions and 121 traditional Chinese medicines, including 14 high-frequency drugs (10 ≥ times), with Rehmannia rehmannia being the most common, with cold and slightly cold medicinal properties being the majority, bitter and sweet medicinal tastes, and the highest proportion of liver meridians in the meridians. The high-frequency drug cluster analysis could be divided into five categories, and the drug pair with the highest support in the association rule analysis was Baixianpi-Baihua snaketongue. Conclusion: Through the analysis of psoriasis vulgaris, which is characterized by stasis and heat interconnection, the treatment of psoriasis vulgaris is mainly to clear heat and detoxify, promote blood circulation and remove stasis, and also dry and damp.

  Key words: Blood stasis and Heat; Psoriasis Vulgaris; Medication Rules; Data Mining; Damp heat in the Spleen and the Stomach

  提交时间：2025-09-26

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-07-08	bmr.202509.00055V1	下载

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