通讯作者: 曾普华, zph120@126.com

DOI：10.12201/bmr.202610.00051

Exploring the differentiation and treatment principles of esophageal cancer based on the

• 摘要：食管癌是消化系统常见恶性肿瘤之一，起病隐匿、进展较快、预后较差，严重影响患者生存质量。中医认为其发生与气滞、痰凝、血瘀、毒聚及正虚密切相关，但病机演变与分阶段辨治规律尚缺乏系统阐释。基于传统中医病因病机理论并结合现代态靶辨治思路，提出食管癌癌毒驱动—态靶同调辨治体系，构建邪毒侵入—痰瘀浊毒—浊毒化癌—癌毒内损的动态演变模式；按不同阶段病机特点，分为癌毒内生态、癌毒内损态与癌毒致虚态，分别确立截毒防变、扶正抗癌、顾护脏腑的分层干预策略；以调气解毒为核心治法，以调气为枢、解毒为要，通过调气机、调升降、调正气与清热解毒、化痰消浊、活血散结、扶正托毒，实现整体调态与局部打靶的协同。该体系有助于深化食管癌中医病机认识，为中西医结合防治食管癌提供新的辨治路径。

  关键词： 食管癌；癌毒驱动；态靶同调；调气解毒；痰瘀毒结; ; ; ; 

   

  Abstract: Esophageal cancer is a common malignant tumor of the digestive tract with insidious onset, rapid progression, and poor prognosis, which markedly impairs patients’ quality of life. In traditional Chinese medicine, its occurrence is closely related to qi stagnation, phlegm congelation, blood stasis, toxin accumulation, and vital qi deficiency; however, the dynamic evolution of its pathogenesis and the stage-based treatment principles remain insufficiently elucidated. By combining traditional etiology and pathogenesis theory with the modern concept of state-target regulation, a cancer toxin-driven state-target co-regulation system for esophageal cancer is proposed, establishing a dynamic progression from toxin invasion and phlegm-stasis turbidity to turbid toxin carcinogenesis and internal depletion of cancer toxin. According to the pathogenic features at different stages, the disease is classified into the cancer toxin generation state, the cancer toxin internal depletion state, and the cancer toxin-induced deficiency state, with layered strategies of intercepting toxin and preventing deterioration, reinforcing vital qi and resisting cancer, and protecting the viscera. With qi regulation as the pivot and detoxification as the key, systemic state regulation and local targeting are coordinated through regulating qi movement, ascending and descending, and vital qi, together with clearing heat and detoxifying, resolving phlegm and eliminating turbidity, activating blood and dissipating masses, and reinforcing vital qi to expel toxin. The model may enrich the understanding of the traditional Chinese medicine pathogenesis of esophageal cancer and provide a new pathway for integrated prevention and treatment.

  Key words: esophageal cancer; cancer toxin-driven; state-target coordinated regulation; regulating qi and removing toxin; phlegm-stasis toxin accumulation

  提交时间：2026-10-22

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2026-08-17	10.12201/bmr.202610.00051V1	下载

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