通讯作者: 胡玉英, 13878847908@163.com

DOI：10.12201/bmr.202610.00032

Mechanisms of m6A Methylation in Regulating Central Nervous System Neurodegenerative Diseases and Advances in Traditional Chinese Medicine Interventions

• 摘要：中枢神经退行性疾病（CNS NDDs）是一组以神经元进行性丢失为核心特征的慢性神经系统疾病，严重危害老龄人群健康，但其发病机制尚未完全阐明。N6-甲基腺苷（m6A）甲基化作为真核生物mRNA最普遍的转录后修饰，广泛参与神经系统发育、炎症反应、细胞凋亡及蛋白稳态等关键过程。而阿尔茨海默病、帕金森病等多种CNS NDDs均存在m6A修饰异常，加剧神经元损伤、异常蛋白聚集与神经炎症，推动疾病进展，目前西医仍缺乏根治手段。近期研究发现，部分中医药凭借多成分、多靶点、整体调节的优势，已被证实可通过靶向m6A甲基化修饰发挥神经保护作用。本文系统综述m6A甲基化修饰的分子机制及其在CNS NDDs中的调控作用，重点梳理中药活性成分及外治法干预m6A甲基化的研究进展，以期为中医药靶向m6A甲基化防治CNS NDDs提供理论依据与研究思路。

  关键词： m6A甲基化; 中枢神经退行性疾病; 帕金森病; 阿尔茨海默病; 综述; ; ; ; 

   

  Abstract: Central nervous system neurodegenerative diseases (CNS NDDs) are a group of chronic neurological disorders characterized by progressive loss of neurons. They seriously endanger the health of the elderly population, but their pathogenesis has not yet been fully elucidated. N6-methyladenosine (m6A) methylation, as the most common post-transcriptional modification in eukaryotic mRNA, is widely involved in key processes such as nervous system development, inflammatory response, cell apoptosis, and protein homeostasis. Abnormal m6A modification exists in various CNS NDDs such as Alzheimer''s disease and Parkinson''s disease, which exacerbates neuronal damage, abnormal protein aggregation, and neuroinflammation, promoting disease progression. Currently, Western medicine still lacks a cure. Recent studies have found that some traditional Chinese medicines, with their advantages of multiple components, multiple targets, and overall regulation, have been proven to exert neuroprotective effects by targeting m6A methylation modification. This article systematically reviews the molecular mechanism of m6A methylation modification and its regulatory role in CNS NDDs, and focuses on summarizing the research progress of active ingredients of traditional Chinese medicines and external treatment methods in regulating m6A methylation, with the aim of providing theoretical basis and research ideas for targeting m6A methylation in the prevention and treatment of CNS NDDs by traditional Chinese medicine.

  Key words: m6A methylation; central nervous system neurodegenerative diseases; Parkinson' ' s disease; Alzheimer' ' s disease; review

  提交时间：2026-10-15

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2026-08-03	10.12201/bmr.202610.00032V1	下载

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