通讯作者: 张嫚茹, njmr234567@163.com

DOI：10.12201/bmr.202602.00097

Correlation between Neuropsychiatric Symptoms and Cognitive Functions in Patients with Alzheimer’s Disease and Mild Cognitive Impairment

• 摘要：目的 探讨阿尔茨海默病（Alzheimer’s disease，AD）、轻度认知障碍（mild cognitive impairment，MCI）患者精神行为症状与认知功能的关系及影响因素。方法 选取AD患者 50 例、MCI 患者69例，健康对照（healthy controls，HC）51例，采用阿尔茨海默病病理行为评分表（behavioral pathology in Alzheimer’s disease rating scale，BEHAVE-AD）评估精神行为症状，简易精神状态检查（mini-mental mtate mxamination，MMSE）、蒙特利尔认知评估量表（Montreal cognitive assessment，MOCA）评估认知，汉密尔顿焦虑量表、汉密尔顿抑郁量表评估情绪，匹兹堡睡眠质量指数（Pittsburgh sleep quality index，PSQI）评估睡眠。统计分析采用Pearson相关分析、协方差分析及多元线性回归分析等。结果 AD组BEHAVE-AD总分、PSQI总分高于MCI组和HC组（P<0.01），MMSE总分、MOCA总分及各因子分低于后两组（P<0.01）；BEHAVE-AD总分与MMSE总分（r=-0.644，P<0.01）、MOCA总分（r=-0.626，P<0.01）呈负相关，与 PSQI 总分（r=0.971，P<0.01）呈正相关；多元线性回归显示，对 BEHAVE-AD 总分，MMSE总分（B =-0.390，P=0.027）、MOCA总分（B =-2.680，P=0.039）呈负向影响，视空间与执行功能（B =0.677，P=0.035）、抽象功能（B =0.438，P=0.017）呈正向影响，模型R2=0.466，P<0.05。结论 阿尔茨海默病及轻度认知障碍患者普遍存在认知功能下降、精神行为症状及睡眠障碍，且精神行为症状随认知功能下降而加重，MMSE、MOCA总分及视空间与执行功能、抽象功能是影响精神行为症状的关键因素，可为临床早期干预提供靶点。

  关键词： 阿尔茨海默病；轻度认知障碍；精神行为症状；认知功能；相关性; ; ; ; 

   

  Abstract: Objective To explore the relationship between neuropsychiatric symptoms and cognitive function, as well as the influencing factors, in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Methods A total of 50 AD patients, 69 MCI patients and 51 healthy controls (HC) were enrolled in the study. Behavioral pathology in Alzheimer’s disease rating scale (BEHAVE-AD) was used to assess neuropsychiatric symptoms. Cognitive function was evaluated by mini-mental state examination (MMSE) and montreal mognitive assessment (MOCA). Anxiety and depressive symptoms were measured using the Hamilton anxiety scale and Hamilton depression scale, respectively. Sleep quality was assessed with Pittsburgh sleep quality index (PSQI). Pearson correlation analysis, analysis of covariance, and multiple linear regression analysis were performed for statistical evaluation. Results The total scores of BEHAVE-AD and PSQI in the AD group were significantly higher than those in the MCI and HC groups (P<0.01), while the total scores of MMSE, MOCA and their respective subscale scores were significantly lower (P<0.01). The total BEHAVE-AD score was negatively correlated with the total MMSE score (r=-0.644, P<0.01) and total MOCA score (r=-0.626, P<0.01), but positively correlated with the total PSQI score (r=0.971, P<0.01). Multiple linear regression analysis showed that the total MMSE score (B=-0.390, P=0.027) and total MOCA score (B=-2.680, P=0.039) had a negative impact on the total BEHAVE-AD score, whereas visuospatial and executive function (B=0.677, P=0.035) and abstract function (B=0.438, P=0.017) exerted a positive impact on it, The model showed a good fit with R2=0.466 (P<0.05). Conclusion Cognitive decline, neuropsychiatric symptoms and sleep disorders are common in AD and MCI patients. Neuropsychiatric symptoms exacerbate with the decline of cognitive function. The total scores of MMSE and MOCA, along with visuospatial and executive function as well as abstract function, are key factors affecting neuropsychiatric symptoms, which can provide potential targets for clinical early intervention.

  Key words: Alzheimers disease; Mild cognitive impairment; Behavioural and psychological symptoms in dementia; Cognitive function; Correlation

  提交时间：2026-02-26

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• 序号	提交日期	编号	操作
  1	2026-01-23	10.12201/bmr.202602.00097V1	下载

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