通讯作者: 陈永欣, 965643897@qq.com

DOI：10.12201/bmr.202605.00100

Research Progress and Prospects of Traditional Chinese Medicines Targeting Ferroptosis and Their Active Ingredients

• 摘要：铁死亡是一种铁依赖性脂质过氧化驱动的调节性细胞死亡形式,与多种疾病的发生发展密切相关。近年来,中药多靶点、多通路调控铁死亡的作用日益受到关注。本文系统综述了中药活性成分通过调节铁代谢、抗氧化系统和脂质过氧化等核心机制干预铁死亡的研究进展,重点分析了姜黄素、黄芪甲苷等代表性成分对铁死亡的调控作用及其在治疗疾病上的应用潜力,同时总结了中药活性成分诱导或抑制铁死亡的最新研究进展,旨在为中药靶向铁死亡治疗疾病的深入研发和干预铁死亡的机制研究提供理论依据,为中药现代化研究和相关疾病治疗提供新思路。

  关键词： 铁死亡; 中药; 脂质过氧化; ; 

   

  Abstract: Ferroptosis is a type of iron-dependent lipid peroxidation-driven regulated cell death that is closely related to the development of various diseases. In recent years, the role of traditional Chinese medicine in regulating ferroptosis through multiple targets and pathways has received increasing attention. This article systematically reviews the research progress on how active components of traditional Chinese medicine interfere with ferroptosis by regulating core mechanisms such as iron metabolism, antioxidant systems, and lipid peroxidation. It focuses on analyzing the regulatory effects of representative components like curcumin and astragaloside IV on ferroptosis and their potential applications in disease treatment. Additionally, it summarizes the latest research advancements on how active components of traditional Chinese medicine induce or inhibit ferroptosis. The aim is to provide a theoretical basis for the in-depth development of traditional Chinese medicine targeting ferroptosis for disease treatment and for research into the mechanisms of ferroptosis regulation. This may also offer new insights for the modernization of traditional Chinese medicine research and the treatment of related diseases.

  Key words: Ferroptosis; Traditional Chinese Medicine; Lipid peroxidation; Iron autophagy; Mitochondria

  提交时间：2026-05-27

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2026-04-11	10.12201/bmr.202605.00100V1	下载

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