通讯作者: 袁阳珍, 1932690159@qq.com

DOI：10.12201/bmr.202604.00092

Clinical observation on the treatment of malignant ascites of ovarian cancer (spleen and kidney yang deficiency type) with compound soap and thorn soup combined with calatin abdominal thermal perfusion

• 摘要：目的:观察复方皂角刺汤联合卡铂腹腔热灌注治疗卵巢癌恶性腹水（脾肾阳虚型）的疗效及安全性。方法:选取常德市第一中医医院2024年11月至2025年11月收治的卵巢癌恶性腹水患者60例，随机分为治疗组和对照组，各30例。对照组予单药卡铂腹腔热灌注化疗，治疗组在对照组基础上加用复方皂角刺汤内服，记录两组患者的治疗总有效率、腹水缓解有效率、恶性腹水腹围、Karnofsky功能状态评分标准（KPS评分）、中医证候积分、血清CA125蛋白水平及不良反应发生率。结果:两组患者治疗前的恶性腹水腹围、KPS评分、中医证候积分、血清CA125蛋白水平比较差异无统计学意义（P>0.05）；治疗后，疗效观察结果显示，治疗组治疗总有效率为90.00%（27/30）高于对照组的73.33%（22/30）（P<0.05）;治疗组腹水缓解有效率为86.66%（26/30）高于对照组的66.67%（20/30）（P<0.05）；治疗后两组患者的恶性腹水腹围减小（P<0.05），中医证候积分和KPS评分下降（P<0.05），血清CA125蛋白水平下降（P<0.05），治疗组均优于对照组。安全性观察结果显示，两组患者的不良反应发生率相当，且安全性高（P>0.05）;结论:复方皂角刺汤联合卡铂腹腔热灌注治疗卵巢癌恶性腹水（脾肾阳虚型）能有效消减恶性腹水，控制病情进展，提高患者生存质量。

  关键词： 卵巢癌; 恶性腹水; 复方皂角刺汤; 卡铂; 脾肾阳虚型

   

  Abstract: : Objective: To observe the efficacy and safety of compound soap horn thorn soup combined with carplatin abdominal heat perfusion in the treatment of ovarian cancer malignant ascites (spleen and kidney yang deficiency type). Methods: 60 patients with ovarian cancer malignant ascites admitted to Changde First Traditional Chinese Medicine Hospital from November 2024 to November 2025 were randomly divided into treatment group and control group, 30 cases each. The control group was given single-drug carplatin abdominal heat perfusion chemotherapy, and the treatment group took the compound soap horn thorn soup on the basis of the control group. The total treatment efficiency, ascites relief efficiency, malignant ascites abdominal circumference, Karnofsky functional status scoring standard (KPS score), traditional Chinese medicine syndrome score, serum were recorded. CA125 protein level and the incidence of adverse reactions. Results: The difference between the abdominal circumference, KPS score, traditional Chinese medicine syndrome score and serum CA125 protein levels of the two groups of patients before treatment was not statistically significant (P>0.05); After treatment, the observation results of therapeutic effect showed that the total treatment efficiency of the treatment group was 90.0% (27/30) higher than that of the 73.33% (22/30) (P<0.05) in the photo group; the ascites relief efficiency of the treatment group was 86.66% (26/30) higher than that of 66.67% (20/30) (P<0.05) in the control group; the malignant ascites abdominal circumference of the two groups of patients after treatment decreased (P<0.05 ), the score of traditional Chinese medicine syndrome and KPS score decreased (P<0.05), and the serum CA125 protein level decreased (P<0.05). The treatment group was better than the control group. Safety observation results show that the incidence of adverse reactions in the two groups of patients is equivalent and the safety is high (P>0.05); Conclusion Compound soap horn thorn soup combined with carplatin abdominal heat perfusion to treat ovarian cancer malignant ascites (spleen and kidney yang deficiency type) can effectively reduce malignant ascites, control the progression of the disease, and improve the quality of survival of patients.

  Key words: : ovarian cancer; malignant ascites; compound soap horn thorn soup; carplatin; spleen and kidney yang deficiency type

  提交时间：2026-04-10

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 田梦娇, 张爱琴. 卵巢癌术后分型辨治经验. 2024. doi: 10.12201/bmr.202411.00016

  兰玲燕, 陈舒铃, 陈昀, 舒琦瑾. 基于数据挖掘探讨专利复方治疗卵巢癌用药规律. 2025. doi: 10.12201/bmr.202510.00008

  胡芷晴, 潘珊, 朱巍立. 铁死亡在逆转卵巢癌铂耐药中的研究进展. 2025. doi: 10.12201/bmr.202512.00070

  陈才月, 向勇, 陈朝霞, 王可文, 钟文亮. 基于“阳虚三夺统于脾”探讨从脾阳虚衰论治糖尿病心肌病. 2026. doi: 10.12201/bmr.202603.00064

  罗子琦, 谢春红, 康  佳. 从肾肝脾治疗早发性卵巢功能不全经验. 2025. doi: 10.12201/bmr.202510.00036

  金宇梦, 李亚平. 调神养心汤治疗心肾不交型围绝经期失眠的临床观察. 2024. doi: 10.12201/bmr.202408.00031

  吴建奇, 黄鸿鹏, 林燕婷, 李寿杰, 陈晓聪. 从逐瘀化饮法辨治恶性腹水经验. 2025. doi: 10.12201/bmr.202503.00011

  许扬坡, 蓝宜盛, 郭安妮, 詹瑷榕. 穴位贴敷对肺肾气虚型COPD稳定期患者运动耐力及心肺功能的临床疗效观察. 2026. doi: 10.12201/bmr.202602.00020

  范灵, 张铭. 右肾缺失单角子宫合并残角子宫并发卵巢子宫内膜异位囊肿一例. 2025. doi: 10.12201/bmr.202504.00055

  钟军, 王明刚, 毛德文, 刘好, 董嘉美, 刘星宇, 林星佐. 基于数据挖掘的中医药治疗肝癌合并腹水的用药规律探析. 2026. doi: 10.12201/bmr.202603.00081

• 序号	提交日期	编号	操作
  1	2026-03-16	10.12201/bmr.202604.00092V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论