通讯作者: 王明刚, wmgyx2012@163.com

DOI：10.12201/bmr.202603.00081

Analysis of medication patterns of Traditional Chinese medicine for liver cancer with ascites based on data mining

• 摘要：目的：挖掘中医药治疗肝癌合并腹水的用药规律。方法：系统检索中国知网、万方、维普数据库，检索时间为2005年1月1日至2025年8月31日期间所有关于中医药治疗肝癌合并腹水的临床研究文献，按照纳入标准筛选文献，构建Excel数据库，运用RStudio进行数据清洗及中药频数统计，采用SPSS Modeler 18.0、SPSS Statistics 31.0进行数据分析。结果：纳入文献22篇，得到中药处方22首，涉及90味中药；中药以补虚药、利水渗湿药、解表药使用居多，中药的药性多为寒、温、平，药味以甘、苦、辛为主，归经则为肝、脾、肺、胃、肾居多；得到12味高频药物；使用频次居前三的药对为黄芪-白术、柴胡-白术、茯苓-白术，较常使用的药物组合为黄芪-柴胡-白术、泽泻-柴胡-白术、茯苓-柴胡-白术；聚类分析可分为调和脾胃类、疏肝健脾利水类、补脾行水类三大类。结论：中医药治疗肝癌合并腹水组方以补法、消法为准则，注重行气利水消肿，不忘调理阴阳，固护脾胃。

  关键词： 肝癌合并腹水; 数据挖掘; 用药规律; 文献研究

   

  Abstract: Objective:To explore the medication patterns of traditional Chinese medicine (TCM) in the treatment of liver cancer with ascites. Methods: A systematic retrieval was conducted in databases such as China National Knowledge Infrastructure (CNKI), Wanfang, and VIP. All clinical research literature on TCM treatment for liver cancer with ascites published between January 1, 2005, and August 31, 2025, was retrieved. Literature was screened according to inclusion criteria, an Excel database was constructed, data cleaning and TCM frequency statistics were performed using RStudio, and data analysis was conducted with SPSS Modeler 18.0 and SPSS Statistics 31.0. Results: A total of 22 articles were included, yielding 22 TCM prescriptions involving 90 types of herbs. The most frequently used TCM categories were tonifying agents, diuretic and dampness-resolving agents, and exterior-releasing agents. The primary properties of the herbs were cold, warm, and neutral, while their primary tastes were sweet, bitter, and pungent. The main meridians targeted were the Liver, Spleen, Lung, Stomach, and Kidney. Twelve high-frequency herbs were identified. The top three most frequently used herb pairs were Astragalus and Atractylodes, Bupleurum and Atractylodes, and Poria and Atractylodes. Commonly used herb combinations included Astragalus-Bupleurum-Atractylodes, Alisma-Bupleurum-Atractylodes, and Poria-Bupleurum-Atractylodes. Cluster analysis categorized the prescriptions into three major types: spleen-stomach harmonizing, liver-soothing, spleen-strengthening, and water-promoting, and water-draining, and spleen-nourishing and water-moving. Conclusion: The prescription principles of TCM for liver cancer with ascites are primarily based on tonification and elimination methods, emphasizing qi-moving, water-promoting, and edema-reducing effects, while also focusing on balancing yin and yang and protecting the spleen and stomach.

  Key words: hepatocellular carcinoma with ascites; data mining; medication patterns; literature review

  提交时间：2026-03-19

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• 序号	提交日期	编号	操作
  1	2026-02-26	10.12201/bmr.202603.00081V1	下载

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