A randomized controlled trial of Jiaoyu RS3 resistant starch in the treatment with atherosclerotic cerebral infarction in convalescent period

Corresponding author: HUANG Xianhui, 18685036490@163.com

DOI: 10.12201/bmr.202509.00025

•  

  Abstract: Objective: Investigation of effect of the characteristic RS3 resistant starch from banana taro (Ce-RS3) on serum homocysteine (Hcy) level in patients with atherosclerotic cerebral infarction (ACI) during the recovery period. Methods: This study was conducted in the Department of Neurology at the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine. The subjects were 60 patients in the convalescent phase of cerebral infarction who were admitted between October 2023 and October 2024. They were divided into an observation group and a control group, each comprising 30 patients, using a computer-generated random sequence. Finally, 28 patients in the observation group and 27 patients in the control group completed the study, with a total of 55 participants successfully finishing the trial. The control group was treated with Atorvastatin Calcium and Aspirin, while the observation group was treated with Atorvastatin Calcium, Aspirin, and Ce-RS3. After 12 weeks of treatment, the levels of Hcy in the blood, carotid artery plaque size, National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI), and changes in Traditional Chinese Medicine (TCM) symptom scores were compared between the two groups. Results: After treatment, the serum Hcy levels decreased and carotid plaque size was reduced in both groups, with the NIHSS scores and TCM syndrome scores also decreased, and the observation group was lower than the control group (p<0.05). After treatment, the BI increased, with the observation group higher than the control group (p<0.05). Conclusion: The results of this study show that Ce-RS3 has a significant effect on stabilizing atherosclerotic plaques and reducing serum Hcy levels, which is helpful to improve the neurological status and treatment efficacy.

  Key words: banana taro RS3 resistant starch; Atherosclerotic?cerebral?infarction; convalescent period; Homocysteine; TCM syndrome.

  Submit time: 9 September 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• Association Between Serum CXCL14 Levels and Carotid Atherosclerotic Plaques in Patients With Type 2 Diabetes Mellitus. 2025. doi: 10.12201/bmr.202506.00073

  Chen Yifei, Tang Xiaoli. Study on Dynamic Technology Opportunity Detection Method Based on Graph Neural Network -- A Case Study of Diagnosis and Treatment of Atherosclerosis. 2025. doi: 10.12201/bmr.202503.00040

  XIE Aoni, ZHOU Ziyi, SUN Liqiang, LAI Junyu, CHEN Zhengtao, WU Jianguang. Research progress on the role of endoplasmic reticulum stress in atherosclerosis based on triple energizer theory. 2025. doi: 10.12201/bmr.202501.00011

  Liu Wei, Cao Jun, Zhang Xiao Mei, Wang Bao Hua, Zhu Hong Qing. Effects of Shugan Huoxue Yishen decoction on homocysteine, inflammatory factors and endothelial function in patients with metabolic syndrome-related erectile dysfunction. 2025. doi: 10.12201/bmr.202508.00012

  HE Lanlan, LI Danyang, SHEN Li, WU Zhonghua, ZHANG Jun, YE Yongqiang. Construction and validation of nomogram model for prolonged length of stay in patients with acute cerebral infarction based on total cerebral small vessel disease burden scores. 2025. doi: 10.12201/bmr.202501.00008

  Tong Mingfu. Correlation between Triglyceride Glucose-body Mass Index, Atherogenic Index of Plasma and Gallstone Disease. 2024. doi: 10.12201/bmr.202411.00068

  杨 欢, LIU Yue. Based on the theory of spleen as cardinal, the role of mitophagy mediating macrophage pyroptosis in atherosclerosis was discussed. 2025. doi: 10.12201/bmr.202508.00029

  lixintai, tonli, yangjw. Contrast agent induced "cerebral infarction" imaging changes: a case of Contrast-induced Encephalopathy and literature review. 2024. doi: 10.12201/bmr.202406.00035

  wangyifan, shichaojun, maanning. Comparison of risk prediction models for atherosclerosis in type 2 diabetes mellitus. 2024. doi: 10.12201/bmr.202404.00007

  wangyuanhang, hehuiying, cuiyuhong. Study on the Mechanism of m6A Modification in Atherosclerosis. 2024. doi: 10.12201/bmr.202412.00056

• ID	Submit time	Number	Download
  1	2025-08-24	bmr.202509.00025V1	Download

• Public  Anonymous  To author only Submit Comments