Based on the theory of spleen as cardinal, the role of mitophagy mediating macrophage pyroptosis in atherosclerosis was discussed

Corresponding author: LIU Yue

DOI: 10.12201/bmr.202508.00029

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  Abstract: Atherosclerosis (AS) is a chronic inflammatory disease of the artery wall. Modern medicine believes that macrophage homeostasis is out of balance, mitochondrial autophagy function is weakened, and macrophage pyroptosis is induced, and then a large number of inflammatory factors are released to cause AS. The inflammatory response can be seen as a microscopic manifestation of phlegm and stasis. The spleen is in the middle of the coke, which is the hub of the lifting of the gas engine. Traditional Chinese medicine believes that the imbalance of the spleen cardinal, the imbalance of qi and organs, the destruction of the balance of the human body, the imbalance of qi, blood and fluid, and the internal obstruction of the veins by phlegm and stasis are the key pathogenesis. Mitochondria are the main source of energy in the cell, and they are the modern biological basis of the spleen in traditional Chinese medicine. Therefore, this paper suggests that mitochondrial autophagy-mediated pyroptosis of macrophages may be a microscopic manifestation of spleen cardinal imbalance and endophytic phlegm stasis. Therefore, the purpose of this paper is to explore the pathological mechanism of mitophagy autophagy-induced pyroptosis in macrophages under the guidance of the theory of spleen as cardinal, enrich the connotation of spleen as cardinal, and provide a theoretical basis for the diagnosis and treatment of AS.

  Key words: spleen; pivot; atherosclerosis; mitophagy; macrophages are pyroptosis

  Submit time: 12 August 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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