Research Progress on the Treatment of Knee Osteoarthritis by Regulating Relevant Signal Pathways with Traditional Chinese Medicine

Corresponding author: Jiang Tao, doctorjt88@163.com

DOI: 10.12201/bmr.202509.00021

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  Abstract: :Knee osteoarthritis (KOA) is a chronic degenerative disease characterized by cartilage degeneration, synovial inflammation and abnormal bone remodeling. Its onset is closely related to the imbalance of inflammatory factors, activation of matrix-degrading enzymes and dysregulation of key signaling pathways. Although traditional treatment methods (such as non-steroidal anti-inflammatory drugs and joint replacement surgery, etc.) can relieve symptoms, they have limitations such as significant side effects and inability to reverse the pathological process. In recent years, traditional Chinese medicine has demonstrated significant potential in regulating signaling pathways such as NF-κB, MAPK, and Wnt/β-catenin to inhibit inflammatory responses, delay cartilage degradation, and promote repair, thanks to its advantages of multi-component, multi-target, and holistic regulation. This article systematically reviews the mechanism of action of single active ingredients of traditional Chinese medicine (such as tripterygiin and icariin) and classic compound prescriptions (such as Duhuo Jiji Decoction) in treating KOA by intervening in key signaling pathways, aiming to provide theoretical basis and research direction for the modernization of KOA treatment with traditional Chinese medicine.

  Key words: Traditional Chinese medicine; Knee osteoarthritis; Signal path

  Submit time: 8 September 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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