通讯作者: 蒋涛, doctorjt88@163.com

DOI：10.12201/bmr.202509.00021

Research Progress on the Treatment of Knee Osteoarthritis by Regulating Relevant Signal Pathways with Traditional Chinese Medicine

• 摘要：膝骨关节炎(KOA)是一种以关节软骨退变、滑膜炎症及骨重塑异常为特征的慢性退行性疾病,其发病与炎症因子失衡、基质降解酶激活及关键信号通路失调密切相关。传统治疗手段(如非甾体抗炎药、关节置换术等)虽能缓解症状,但存在副作用大、无法逆转病理进程等局限性。近年来,中药凭借多成分、多靶点、整体调节的优势,在调控NF-κB、MAPK、Wnt/β-catenin等信号通路以抑制炎症反应、延缓软骨降解及促进修复方面展现出显著潜力。本文系统综述了单味中药活性成分(如雷公藤甲素、淫羊藿苷)、经典复方(如独活寄生汤)通过干预关键信号通路治疗KOA的作用机制,旨在为中医药现代化治疗KOA提供理论依据与研究方向。

  关键词： 中医药; 膝骨关节炎; 信号通路

   

  Abstract: :Knee osteoarthritis (KOA) is a chronic degenerative disease characterized by cartilage degeneration, synovial inflammation and abnormal bone remodeling. Its onset is closely related to the imbalance of inflammatory factors, activation of matrix-degrading enzymes and dysregulation of key signaling pathways. Although traditional treatment methods (such as non-steroidal anti-inflammatory drugs and joint replacement surgery, etc.) can relieve symptoms, they have limitations such as significant side effects and inability to reverse the pathological process. In recent years, traditional Chinese medicine has demonstrated significant potential in regulating signaling pathways such as NF-κB, MAPK, and Wnt/β-catenin to inhibit inflammatory responses, delay cartilage degradation, and promote repair, thanks to its advantages of multi-component, multi-target, and holistic regulation. This article systematically reviews the mechanism of action of single active ingredients of traditional Chinese medicine (such as tripterygiin and icariin) and classic compound prescriptions (such as Duhuo Jiji Decoction) in treating KOA by intervening in key signaling pathways, aiming to provide theoretical basis and research direction for the modernization of KOA treatment with traditional Chinese medicine.

  Key words: Traditional Chinese medicine; Knee osteoarthritis; Signal path

  提交时间：2025-09-08

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-07-24	bmr.202509.00021V1	下载

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