通讯作者: 虞跃跃, tcmyuyueyue@ncst.edu.cn

DOI：10.12201/bmr.202502.00016

Ancient data mining on drug characteristics of knee osteoarthritis

• 摘要：目的 分析古代文献治疗膝骨关节炎的方剂，探索方药应用规律，为临床治疗膝骨关节炎提供借鉴。方法 收集古代文献治疗膝骨关节炎的方剂，使用 Excel 2016建立数据库，并进行频数分析，应用 SPSS Modeler 18.0软件、Lantern 5.0进行关联规则和隐结构模型分析，从而多维度的探讨古代文献治疗膝骨关节炎的规律。结果 共收集方剂373首，中药421种，总计用药频次为3894次，其中频次最高为当归，药物功效以补虚、解表、祛风湿为主，药性偏温，药味偏辛、甘、苦，归经多归脾、肾经。关联规则分析共得到13条强关联规则，其中川芎+牛膝→当归，萆薢→牛膝为主要强关联规则。通过隐结构分析共得到 10个隐变量，根据中医学知识推断得到 4个综合聚类和4个核心方剂，推断古籍文献中常见证候有风湿型膝痹证、风寒湿型膝骨关节炎、风湿热型膝骨关节炎、气血亏虚型膝骨关节炎。 结论 古代文献治疗膝骨关节炎以祛风除湿为核心策略，同时根据分型兼顾正虚与邪实，灵活运用补脾肾、清湿热、补气血等药物进行治疗。

  关键词： 隐结构 关联规则分析 用药规律 膝骨关节炎; ; ; 

   

  Abstract: Objective This paper analyzes the prescriptions for the treatment of knee osteoarthritis in ancient literature, and explores the application rules of prescriptions, so as to provide reference for the clinical treatment of knee osteoarthritis.Methods The prescriptions for the treatment of knee osteoarthritis in ancient literature were collected, and the database was established by Excel 2016, and the frequency analysis was carried out. The association rules and hidden structure model were analyzed by SPSS Modeler 18.0 software and Lantern 5.0.Therefore, the regularity of the treatment of knee osteoarthritis in ancient literature was discussed in multi-dimension. Results A total of 373 prescriptions and 421 kinds of traditional Chinese medicine were collected, with a total frequency of 3894,the highest frequency is Angelica, the drug effect is mainly tonifying deficiency, relieving surface, expelling wind and dampness, the drug is warm, the drug taste is mild, sweet, bitter, and more return to spleen and kidney channels. A total of 13 strong association rules were obtained from the analysis of association rules, among which Chuanxiong + Achyranthes Radix → Angelica rhizome, Dioscorea rhizome → Achyranthes radix Rhizome were stronger.A total of 10 hidden variables were obtained by hidden structure analysis, and 4 comprehensive clustering and 4 core prescriptions were inferred according to the knowledge of traditional Chinese medicine. It is inferred that the common syndromes in ancient literature are rheumatic knee arthralgia syndrome, wind-cold-damp knee osteoarthritis, rheumatic heat knee osteoarthritis, qi and blood deficiency knee osteoarthritis. Conclusion The treatment of knee osteoarthritis in ancient literature takes expelling wind and dehumidification as the core strategy, while taking into account both deficiency and evil according to the classification, and flexibly use drugs such as tonifying spleen and kidney, clearing dampness and heat, tonifying qi and blood and so on.

  Key words: latent structure; Association rule analysis; medication law; Knee osteoarthritis

  提交时间：2025-02-11

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-01-20	bmr.202502.00016V1	下载

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