Research on the pattern of traditional Chinese medicine compounding based on the national patent compound formula for the treatment of Hashimotos thyroiditis

Corresponding author: chen ji dong, dondong@139.com

DOI: 10.12201/bmr.202508.00015

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  Abstract: Objective To analyze the medication pattern of national patents for the prevention and treatment of Hashimotos thyroiditis by means of data mining technology, so as to provide reference for clinical diagnosis and treatment and new drug development. Methods To summarize the Chinese medicine compound patents for the prevention and treatment of Hashimotos thyroiditis in the patent database of the State Intellectual Property Office and the patent database of China Knowledge Network, with the search time from the establishment of the database to December 31, 2024, with the help of Excel 2019, the ancient and modern medical case cloud platform, and other data mining software, we analyzed the frequency of use of the patented compound Chinese medicines, the sex and flavor attribution, the rules of association, the clustering of medicines, and the complex network, and so on. Results Through screening, a total of 57 patented compound prescriptions met the inclusion criteria, involving 215 Chinese medicines, and the top 6 Chinese medicines with higher frequency of use were Astragalus, Chaihu, Xiaku Cao, Paeonia lactiflora, Glycyrrhiza glabra, and Poria. The medicinal properties were mainly cold, calm and warm, and the flavors were mainly bitter, sweet and pungent; the categorization of meridians was most in the liver meridian, followed by the spleen meridian and lung meridian. There were three groups of strongly related pairs of drugs and one group of angular drugs, and a total of four high-frequency drug combinations were obtained by cluster analysis. Conclusion The basic pathogenesis of Hashimotos thyroiditis is mostly based on the internal deficiency of positive qi, and the stagnation of qi, blood stasis, and phlegm congealment at the galls as the symptoms, which is the evidence of the deficiency of the root and the mixture of deficiencies and realities. Clinical use of deficiency tonifying drugs such as astragalus, licorice,codonopsis, atractylodes, etc. to strengthen the root, liver-dispersing drugs such as Chai Hu, Xiang Fu, etc., phlegm-dispersing drugs such as Xia Ku Cao, Zhe Bei Mu, etc., blood stasis activating drugs such as Angelica sinensis, Rhizoma Ligusticum Chuanxiong, Salviae Miltiorrhizae, etc.,in order to treat the symptom.

  Key words: Hashimotos thyroiditis; national patent; data mining; dispensing law

  Submit time: 6 August 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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