The mechanisms of action of SGLT2i in the treatment of heart failure and recent research advances

Corresponding author: WU Xiayang, 56425477@qq.com

DOI: 10.12201/bmr.202507.00052

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  Abstract: Heart failure (HF) is a terminal stage of various cardiovascular diseases, characterized by high incidence and mortality rates. Therefore, reducing hospital readmission rates and mortality risk in patients is a major therapeutic goal at present. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) were initially developed and marketed as a novel class of oral antidiabetic drugs for the treatment of diabetes. Clinical studies have already demonstrated that these drugs can effectively improve the prognosis of patients with HF. This article focuses on the mechanisms of action of SGLT2i and their application in the treatment of HF, aiming to provide new insights and perspectives for the management of HF patients.

  Key words: SGLT2i; heart failure; mechanisms of action; clinical trial

  Submit time: 16 July 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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