Ferroptosis and endoplasmic reticulum stress in polycystic ovary syndrome and related potential therapeutic targets

Corresponding author: Liu Lingyan, Lingyan@ccmu.edu.cn

DOI: 10.12201/bmr.202507.00042

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  Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disorder in young and middle-aged women. Ferroptosis is a non-apoptotic programmed cell death mode driven by peroxidation of specific membrane lipids. Endoplasmic reticulum stress is closely associated with cell death and plays a role in chronic metabolic diseases. Recent studies have found that ferroptosis and endoplasmic reticulum stress play an important part in the development of PCOS. Therefore, this review summarizes the mechanisms of ferroptosis and endoplasmic reticulum stress in PCOS, and also focuses on the latest research progress of targeting ferroptosis and endoplasmic reticulum stress with drugs to alleviate PCOS, which will provide valuable information for the systemic treatment of PCOS.

  Key words: polycystic ovary syndrome, ferroptosis, endoplasmic reticulum stress; ; 

  Submit time: 14 July 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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