Effects of common environmental pollutants on non-alcoholic fatty liver disease

Corresponding author: Chen Zhiyun, jcyjzxchen@163.com

DOI: 10.12201/bmr.202506.00049

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  Abstract: The liver is the main detoxification organ of the human body and often reflects the health of the body.In the past decades, non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide, jeopardizing the health of the human body and constantly increasing the socio-economic burden.NAFLD, as a multifactorial disease NAFLD, as a multifactorial disease, is closely related to metabolic disorders. In recent years, technological advances and industrialization have also led to an increase in the release of pollutants into the environment, such as pesticides, heavy metals, and plastics. More and more studies have revealed the potential harmful effects of environmental pollutants on the liver, especially on the occurrence and development of NALFD. This suggests that we need to gain a deeper understanding of the mechanism of action of environmental pollutants on NAFLD in order to find appropriate interventions to reduce their damage to the liver. This review aims to improve the understanding of the effects of several common environmental pollutants on the mechanisms of NAFLD development.

  Key words: Non-alcoholic fatty liver disease; environmental pollution; chemical mixture; heavy metals; air pollution

  Submit time: 20 June 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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