通讯作者: 陈芝芸, jcyjzxchen@163.com

DOI：10.12201/bmr.202506.00049

Effects of common environmental pollutants on non-alcoholic fatty liver disease

• 摘要：肝脏是人体主要的解毒器官，往往反映着人体的健康情况，过去的几十年中，非酒精性脂肪性肝病（Non-alcoholic fatty liver disease,NAFLD）已经成为世界范围内最普遍的肝病，危害人体的健康，不断增加社会经济负担。NAFLD作为一种多因素疾病，与代谢紊乱密切相关。近年来，技术的进步和工业化也导致了环境中污染物排放的增加，例如杀虫剂、重金属、塑料等。越来越多的研究揭示了环境污染物对于肝脏的潜在危害，特别是对NALFD的发生和发展起着重要的作用。这提示我们需要深入了解环境污染物对于NAFLD的作用机制，以便寻找合适的干预措施减少其对肝脏的损害。本综述旨在提高几种常见环境污染物对于NAFLD发展机制影响的认识。

  关键词： 非酒精性脂肪性肝病；环境污染；化学混合物；重金属；空气污染; ; ; ; 

   

  Abstract: The liver is the main detoxification organ of the human body and often reflects the health of the body.In the past decades, non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide, jeopardizing the health of the human body and constantly increasing the socio-economic burden.NAFLD, as a multifactorial disease NAFLD, as a multifactorial disease, is closely related to metabolic disorders. In recent years, technological advances and industrialization have also led to an increase in the release of pollutants into the environment, such as pesticides, heavy metals, and plastics. More and more studies have revealed the potential harmful effects of environmental pollutants on the liver, especially on the occurrence and development of NALFD. This suggests that we need to gain a deeper understanding of the mechanism of action of environmental pollutants on NAFLD in order to find appropriate interventions to reduce their damage to the liver. This review aims to improve the understanding of the effects of several common environmental pollutants on the mechanisms of NAFLD development.

  Key words: Non-alcoholic fatty liver disease; environmental pollution; chemical mixture; heavy metals; air pollution

  提交时间：2025-06-20

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 王馨雨, 张淑娟. GLP-2在非酒精性脂肪性肝病中的研究进展. 2025. doi: 10.12201/bmr.202502.00018

  彭玉冰, 牛晓珊. NF-κB在非酒精性脂肪肝病中的药物研究进展. 2024. doi: 10.12201/bmr.202410.00006

  贾晨, 巩 艳, 韩懿晶, 姜佳楠, 刘唯正, 张大旭, 吕文平. 心理压力与代谢相关脂肪性肝病的相关性研究. 2022. doi: 10.12201/bmr.202204.00003

  刘萌萌, 李雪, 费悦, 徐霞红. 基于NHANES数据库探索血清铁蛋白与青少年代谢相关脂肪性肝病的相关性. 2025. doi: 10.12201/bmr.202503.00012

  易小莲. 儿童代谢相关脂肪性肝病的治疗与研究进展. 2025. doi: 10.12201/bmr.202507.00044

  郭慧芳, 沈沛成. 慢性肾脏病中医非药物疗法研究概述. 2024. doi: 10.12201/bmr.202409.00054

  刘迷迷, 杜国霞, 周毅, 吴斌, 吴晓瑛. 肝硬化专病数据库建设与应用研究. 2021. doi: 10.12201/bmr.202104.00014

  陈书逸, 何飞. “保胃气”在辨治非结核分枝杆菌肺病的应用. 2024. doi: 10.12201/bmr.202407.00002

  郑洁, 张真稳. SGLT2抑制剂对代谢综合征各组分的影响. 2025. doi: 10.12201/bmr.202503.00002

  孙楚为, 沈喆珺, 朱冠霖, 叶繁, 杨链, 李鸣. 膳食纤维经短链脂肪酸影响骨代谢的研究进展. 2025. doi: 10.12201/bmr.202504.00008

• 序号	提交日期	编号	操作
  1	2025-06-02	bmr.202506.00049V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论