Advancing in treating Duodenal-Type Follicular Lymphoma

Corresponding author: HuBeili, 87718916@qq.com

DOI: 10.12201/bmr.202504.00010

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  Abstract: Duodenal-Type Follicular Lymphoma (DFL) is a rare follicular lymphoma, which often involves the second segment (lower part) of the duodenum, accounting for about 4% of gastrointestinal follicular lymphoma. At present, the pathogenesis of DFL is unclear, which may be related to genetic changes, cells with unique origin, changes in the immune microenvironment, Helicobacter pylori infection, gene mutation, etc. DFL usually has a good prognosis, but some patients may progress to invasive lymphoma. Because this disease is rare and the long-term clinical prognosis is unclear, there is no clear recommendation on the best treatment plan for DFL. This article summarizes follow-up observation, chemotherapy, radiotherapy, immunotherapy, targeted treatment, etc., in order to provide new ideas for the treatment of DFL.

  Key words: Duodenal follicular lymphoma; watch and wait strategy; radiotherapy; immunotherapy; targeted therapy

  Submit time: 7 April 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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