Clinical research progress of PD-1/PD-L1 inhibitor induction therapy in unresectable stage III non-small-cell lung cancer

DOI: 10.12201/bmr.202501.00025

•  

  Abstract: Non-small-cell lung cancer (NSCLC) is the most common malignant tumor, and its incidence and mortality rate rank first in China. For patients with unresectable locally advanced NSCLC, radical concurrent chemoradiotherapy(cCRT) has been the standard treatment for a long time. However, less than 30% of patients in China actually receive radical cCRT, and more patients adopt sequential CRT. Therefore, how to further optimize the mode of CRT has been a research hotspot. Based on the PACIFIC study and the GEMSTONE-301 study, giving immunotherapy as consolidation after CRT has become the standard treatment for patients with unresectable locally advanced NSCLC. However, about 1/4 of these patients still failed due to tumor progression or toxic reactions during CRT. In order to improve the efficacy of these patients, studies on immune-induction therapy has emerged. PD-1/PD-L1 inhibitors are the most commonly used immunotherapy in China. This paper summarized the latest clinical study on the immune-induction therapy model, such as immune-monotherapy(AFT-16 study), immunotherapy combined with chemotherapy (KEYNOTE-799 study, GASTO-1091 study), and immunotherapy combined with chemotherapy and anti-VEGFR-targeted therapy (GASTO-1086 study). These studies have preliminarily demonstrated the feasibility and safety of immune-induction therapy in patients with unresectable locally advanced NSCLC. However, since most of the current clinical studies are single-arm or retrospective studies, it still needs further support from more phase Ⅲ randomized controlled study data.

  Key words: Carcinoma, Non-Small-Cell Lung; Immune Checkpoint Inhibitors; Neoadjuvant Therapy; Radiotherapy.

  Submit time: 9 January 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• 李娜, Luo bingqing. Clinical observation of microwave ablation combined with chemotherapy and PD-1 inhibitor for non-small cell lung cancer.. 2025. doi: 10.12201/bmr.202504.00054

  QIAN Yun. Adverse events associated with immune checkpoint inhibitors: clinical manifestations and mechanisms. 2025. doi: 10.12201/bmr.202502.00010

  Li Ying, Wang Xiaofei, Lu Shengwei, Dong Danni, Zhang Jingfeng, Zheng Jianjun. CT Findings and Clinical Features of checkpoint Inhibitor-related pneumonitis. 2024. doi: 10.12201/bmr.202407.00008

  Houyu, Liyong, Zhouweixing, Liyaozaho, Lili. Progress in the study of cryoablation-induced immune effects and combined immunotherapy. 2025. doi: 10.12201/bmr.202503.00061

  Jing ZHAO, Junxia HUANG, Xiuhua TANG, Hong WANG. The role of HOXA11-AS/miR-149-3p pathway in the malignant phenotype of lung squamous cell carcinoma. 2022. doi: 10.12201/bmr.202204.00005

  Wang Yaoqiang, Wang Haohao, Luo Changjiang. The role of HMGB1 in the progression and therapy of Gastric Cancer. 2024. doi: 10.12201/bmr.202412.00009

  LUAN Zhi-Yong. Research progress of stem cell therapy for Hirschsprung disease. 2024. doi: 10.12201/bmr.202410.00021

  Yuan Heqing, Shao Xiying. . 2025. doi: 10.12201/bmr.202504.00058

  Yadian Lei, Haiyan Wang. The Impact of the Tumor Immune Microenvironment on T Cell Function: Focusing on the Limitations of ICB and Combined Treatment Strategies. 2024. doi: 10.12201/bmr.202412.00083

  ChenYu, libowen, yangjinhua, liuyang, weiyunwei. Research progress and prospect of targeted therapy of microflora in hepatocellular carcinoma. 2024. doi: 10.12201/bmr.202412.00033

• ID	Submit time	Number	Download
  1	2024-12-23	bmr.202501.00025V1	Download

• Public  Anonymous  To author only Submit Comments