Research Progress of microRNA in Regulating Cardiomyocytes and Coronary Endothelial Cells in Myocardial Ischemia-Reperfusion Injury

Corresponding author: CHEN Chunling, 1527693169@qq.com

DOI: 10.12201/bmr.202606.00023

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  Abstract: Myocardial ischemia-reperfusion injury (MIRI) refers to a paradoxical phenomenon in which the restoration of blood flow to the myocardium following a period of ischemia leads to more severe myocardial damage and dysfunction than that caused by persistent ischemia. MicroRNAs (miRNAs) play important roles in MIRI by participating in the regulation of various signaling pathways, including oxidative stress, calcium overload, inflammatory responses, apoptosis, autophagic imbalance, and mitochondrial dysfunction. Therefore, investigating the mechanisms of miRNA action is of great significance for understanding the pathophysiology of MIRI and for developing relevant therapeutic strategies. This review focuses on cardiomyocytes and coronary endothelial cells, and summarizes the core molecular mechanisms by which miRNAs regulate MIRI, their potential for clinical application, as well as the current problems and challenges.

  Key words: Myocardial Ischemia-Reperfusion Injury; microRNA; Apoptosis; Autophagy

  Submit time: 8 June 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-05-12	10.12201/bmr.202606.00023V1	Download

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