Mechanisms and Research Progress of Peripheral Blood Endothelial Progenitor Cells in Angiogenesis and Neural Repair After Traumatic Brain Injury

Corresponding author: yuanyu, autofan100@sina.com

DOI: 10.12201/bmr.202601.00072

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  Abstract: Traumatic brain injury (TBI) is a common and life-threatening neurological disease with a high incidence rate, as well as high rates of disability and mortality. Its pathophysiological mechanisms are complex and clinical therapeutic approaches are limited, which has made it a key research direction in basic and clinical medicine for a long time. Therefore, relevant research has always been a major focus and difficulty in both clinical and basic medical fields. Recent studies have shown that endothelial progenitor cells (EPCs) play an important role in the repair of the blood-brain barrier, angiogenesis, neurogenesis and other processes. Although the potential functions of EPCs in TBI have gradually attracted attention, systematic research on their underlying mechanisms remains relatively limited. This review summarizes the functional roles, phenotypic classification, mobilization mechanisms and research significance of circulating EPCs in patients with TBI, aiming to reveal the importance of EPCs in TBI and provide a reference for the diagnosis, treatment and prognostic evaluation of related neurological diseases

  Key words: Endothelial progenitor cells; Craniocerebral injury; Angiogenesis; Nerve repair; Cell function

  Submit time: 26 January 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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