Effect of sarcopenia on health outcomes in patients with acute decompensated heart failure: a Meta-analysis

Corresponding author: Li aixian, 346397618@qq.com

DOI: 10.12201/bmr.202602.00067

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  Abstract: Objective: To systematically evaluate the impact of sarcopenia on the health outcomes of patients with acute decompensated heart failure (ADHF). Methods: Computerized searches were performed in PubMed, Web of Science, Embase, Cochrane Library, CBM, CNKI, Wanfang Data, and VIP Database to collect studies on the association between sarcopenia and health outcomes in ADHF patients. The search period spanned from the establishment of each database to November 18, 2025. Two researchers independently screened the literature, extracted data, and assessed the methodological quality of the included studies in accordance with the inclusion and exclusion criteria. Statistical analyses were conducted using RevMan 5.4 and Stata 18.0 software. Results: A total of 9 studies were finally included. Meta-analysis results showed that sarcopenia significantly increased the risk of all-cause mortality HR=1.60, 95% CI (1.40, 1.83), P<0.00001, cardiovascular mortality HR=1.75, 95% CI (1.03, 2.97), P=0.04, and composite adverse outcomes HR=2.67, 95% CI (1.15, 6.20), P=0.02 in ADHF patients. Subgroup analysis revealed that non-imaging-assessed sarcopenia had no significant effect on cardiovascular mortality HR=1.16, 95% CI (0.75, 1.79), P=0.51, while imaging-assessed sarcopenia significantly increased the risk of cardiovascular mortality HR=2.72, 95% CI (1.79, 4.14), P<0.00001. Conclusion: Sarcopenia has important predictive value for the prognosis of ADHF patients. Clinical practice should attach importance to the assessment of sarcopenia in ADHF patients and develop targeted intervention measures to reduce the risk of adverse health outcomes.

  Key words: Acute decompensated heart failure; Sarcopenia; Prognosis; Meta-analysis

  Submit time: 14 February 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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