Research progress on ferroptosis in the prevention and treatment of atherosclerosis

Corresponding author: zhangning, Zhangning_nico@163.com

DOI: 10.12201/bmr.202602.00022

•  

  Abstract: The pathogenesis of atherosclerosis (AS) remains complex and not yet fully elucidated. Ferroptosis, a form of programmed cell death, has emerged as a significant focus in recent AS research. This article systematically reviews the association between atherosclerosis and ferroptosis, discussing the mechanisms by which ferroptosis contributes to the development and progression of atherosclerosis. Through a comprehensive analysis of relevant literature, it explores the interplay between oxidative stress, lipid metabolism, inflammation, gut microbiota, apoptosis, and ferroptosis, as well as their impact on the development and progression of atherosclerosis. By delving into the mechanisms through which ferroptosis influences atherosclerosis, this study offers novel insights and directions for therapeutic interventions targeting atherosclerosis.

  Key words: Ferroptosis; Atherosclerosis; Oxidative stress; Inflammation; ; 

  Submit time: 6 February 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• CHANG Yang, WU Daoxiong, LI Qianqian, FENG Qian, WANG Weiwei. Ｒeview of researches on Nrf2 in oxidative stress-induced atherosclerosis. 2025. doi: 10.12201/bmr.202503.00016

  XIE Aoni, ZHOU Ziyi, SUN Liqiang, LAI Junyu, CHEN Zhengtao, WU Jianguang. Research progress on the role of endoplasmic reticulum stress in atherosclerosis based on triple energizer theory. 2025. doi: 10.12201/bmr.202501.00011

  wangyuanhang, hehuiying, cuiyuhong. Study on the Mechanism of m6A Modification in Atherosclerosis. 2024. doi: 10.12201/bmr.202412.00056

  Chen Yifei, Tang Xiaoli. Study on Dynamic Technology Opportunity Detection Method Based on Graph Neural Network -- A Case Study of Diagnosis and Treatment of Atherosclerosis. 2025. doi: 10.12201/bmr.202503.00040

  Li jie. Research Progress on the Treatment of Carotid Atherosclerotic Plaques with Traditional Chinese Medicine. 2025. doi: 10.12201/bmr.202512.00072

  wangyifan, shichaojun, maanning. Comparison of risk prediction models for atherosclerosis in type 2 diabetes mellitus. 2024. doi: 10.12201/bmr.202404.00007

  杨 欢, LIU Yue. Based on the theory of spleen as cardinal, the role of mitophagy mediating macrophage pyroptosis in atherosclerosis was discussed. 2025. doi: 10.12201/bmr.202508.00029

  Liu Lingyan. Ferroptosis and endoplasmic reticulum stress in polycystic ovary syndrome and related potential therapeutic targets. 2025. doi: 10.12201/bmr.202507.00042

  yanglin, yangyang. Research Progress on Autophagy-Dependent Ferroptosis in Cancer. 2024. doi: 10.12201/bmr.202410.00029

  胡芷晴, Pan Shan, Zhu Weili. Advances in Research on Ferroptosis Reversing Platinum Resistance in Ovarian Cancer. 2025. doi: 10.12201/bmr.202512.00070

• ID	Submit time	Number	Download
  1	2026-01-27	10.12201/bmr.202602.00022V1	Download

• Public  Anonymous  To author only Submit Comments