Mounier-Kuhn syndrome: report of two cases and literature review

Corresponding author: Luo Sheng, tcm2007@163.com

DOI: 10.12201/bmr.202504.00057

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  Abstract: 【 】 Objective: To analyze and summarize the etiology and clinical characteristics of Mounier-Kuhn syndrome (MKS), so as to improve the understanding of the disease. Methods: Two cases of MKS diagnosed in our hospital were reported, and their clinical features and imaging findings were analyzed. CNKI, Wanfang, Pubmed, and Web of Science databases were searched to screen out high-quality case reports of MKS for systematic review. Results: A total of 240 patients with MKS were included in this study. The etiology of MKS was not clear, and males were more common. The pathological features were atrophy and slender elastic fibers and smooth muscle tissue of the trachea and main bronchus, and obvious tracheal bronchiectasis was seen on chest CT and bronchoscopy. There is no effective treatment for this disease. At present, anti-infective therapy is the main treatment, and tracheal stent implantation is feasible in a few cases. Conclusions: MKS is a rare respiratory disease, which is not related to smoking history. It can be diagnosed by chest CT or bronchoscopy.

  Key words: Mounier-Kuhn syndrome; Literature review

  Submit time: 18 April 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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