通讯作者: 汪玲莉, WLL19791011@163.com

DOI：10.12201/bmr.202510.00027

Discussion on the Etiology, Pathogenesis, Prevention and Treatment of Persistent High-Risk HPV Infection Based on “Latent Pathogen” Theory

• 摘要：高危型人乳头瘤病毒(HR-HPV)持续感染作为宫颈癌发病及宫颈癌前病变进展的前提条件,已成为当前学术领域的研究热点。本研究旨在通过深入探究HR-HPV持续感染与中医“伏邪”理论的内在联系,深化对其病理本质的认知并拓宽临床诊疗思路。通过将“伏邪”理论与HR-HPV“湿毒伏于胞宫,正虚邪恋迁延”的核心病机相结合,系统地揭示了中医病理机制,提出以湿、热、虚、毒为靶点,通过调补肝脾肾以扶正、清泄湿热毒以祛邪的防治策略,为临床实践提供切实有效的指导。

   

  Abstract: Persistent infection with high-risk human papillomavirus (HR-HPV) has emerged as a prominent concern in the field of cervical lesions in recent years. To deepen the understanding of its pathological essence and expand clinical diagnostic and therapeutic approaches, this study explores the intrinsic association between persistent HR-HPV infection and the theory of latent pathogens in traditional Chinese medicine (TCM). Specifically, it integrates the latent pathogen theory with the core TCM pathogenesis of HR-HPV infection—characterized as dampness-toxin lurking in the uterine cavity and lingering pathogenic factors amid vital qi deficiency—to systematically elucidate its TCM pathological mechanisms. Building on this, the study proposes a therapeutic strategy of combining reinforcement and elimination, targeting the four key pathogenesis elements (dampness, heat, deficiency, and toxin). This strategy involves regulating and tonifying the liver, spleen, and kidney to strengthen vital qi while clearing away dampness, heat, and toxin to expel pathogens, thereby providing guidance for clinical practice.

  提交时间：2025-10-16

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-08-15	bmr.202510.00027V1	下载

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