颜莉, 邹迪. 基于“喉肾相关”探讨扁桃体感染与IgA肾病的相关性. 2025. biomedRxiv.202508.00043
基于“喉肾相关”探讨扁桃体感染与IgA肾病的相关性
通讯作者: 邹迪, aggiezou@163.com
DOI:10.12201/bmr.202508.00043
Exploring the Association Between Tonsillar Infection and IgA Nephropathy Based on the Theory of the Throat-Kidney Axis
Corresponding author: Zou Di, aggiezou@163.com
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摘要:基于中医“喉肾相关”理论,为系统探讨扁桃体感染与IgA肾病的关联性及其病理机制与临床意义。通过结合中西医理论视角深入分析,并总结现代中医“从咽论治”IgAN的临床实践与实验研究进展。分析表明,中西医在“喉肾相关”与“黏膜-肾脏轴”理论上存在共通性,共同揭示了扁桃体感染作为IgAN发病和进展关键诱因的生物学基础。最终论述指出,未来研究需深入探索扁桃体局部免疫微环境对IgAN的特异性调控机制,并积极推动相关中西医结合防治策略的临床转化,为IgAN的防治提供新思路。
Abstract: Systematically exploring the association between tonsillar infection and IgA nephropathy (IgAN), along with its pathological mechanisms and clinical significance, is grounded in the Traditional Chinese Medicine (TCM) theory of larynx-kidney correlation . An in-depth analysis integrating perspectives from both TCM and Western medicine (WM) summarizes recent advances in clinical practice and experimental research concerning the modern TCM throat-targeted therapeutic approach for IgAN. Analysis demonstrates significant commonality between the TCM larynx-kidney correlation concept and the WM mucosa-kidney axis theory, collectively revealing the biological basis establishing tonsillar infection as a key trigger for IgAN onset and progression. The discussion concludes that future research requires deeper exploration into the specific regulatory mechanisms of the tonsillar immune microenvironment on IgAN pathogenesis. Furthermore, active promotion of clinical translation for integrated TCM-WM prevention and treatment strategies is warranted to provide novel insights for IgAN management.
Key words: IgA nephropathy (IgAN); Throat-Kidney Axis; Pharyngeal therapy; Tonsillar infection提交时间:2025-08-22
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序号 提交日期 编号 操作 1 2025-08-14 bmr.202508.00043V1
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