通讯作者: 周晶, 1500043074@qq.com

DOI：10.12201/bmr.202505.00012

Research on the Expression of SLPI in Cervical Adenocarcinoma and Its Correlation with HPV Infection

• 摘要：目的: 探讨分泌型白细胞蛋白酶抑制因子(SLPI)在宫颈腺癌(AC)及宫颈原位腺癌(AIS)中的表达及临床病理意义,分析SLPI表达与人乳头瘤病毒(HPV)感染相关性。方法:对长沙市中心医院病理科2019年—2022年期间诊断为宫颈腺体病变组织87例进行SLPI蛋白的免疫组织染色及HPV基因检测,探寻SLPI在AC及AIS及正常宫颈腺体中的表达情况,分析其表达水平与AC患者临床病理特征及HPV感染之间的相关性。结果: SLPI在AIS及AC组织中的表达低于正常宫颈组织(P＜0.05)； SLPI的表达与HPV感染之间呈负相关(r=-0.353,P＜0.05)； SLPI的表达与AC的组织学分化、HPV感染、脉管侵犯、淋巴结转移、Silva分型及FIGO分期显著相关(P＜0.05)。结论:SLPI在宫颈腺癌中低表达,与侵袭性的生物学病理特征密切相关,且SLPI低表达与HPV感染相关,提示SLPI可能作为抑癌因子参与宫颈腺癌的进展,其SLPI表达下降可能提示HPV感染,SLPI有望成为宫颈腺癌诊疗及预后的潜在生物标志物。

  关键词： 分泌型白细胞蛋白酶抑制因子；宫颈原位腺癌；宫颈腺癌；人乳头瘤病毒; ; ; 

   

  Abstract: Objective: To explore the expression and clinicopathological significance of secretory leukocyte protease inhibitor (SLPI) in cervical adenocarcinoma (AC) and adenocarcinoma in situ (AIS) of the cervix, and to analyze the correlation between SLPI expression and human papillomavirus (HPV) infection.Methods:Immunohistochemical staining of SLPI protein and HPV gene detection were performed on 87 cases of cervical glandular lesion tissues diagnosed in the Department of Pathology, Changsha Central Hospital from 2019 to 2022. The expression of SLPI in AC, AIS, and normal cervical glands was explored, and the correlation between its expression level and the clinicopathological characteristics of AC patients and HPV infection was analyzed. Results:The expression of SLPI in AIS and AC tissues was lower than that in normal cervical tissues (P < 0.05). There was a negative correlation between the expression of SLPI and HPV infection (r=-0.353, P < 0.05). The expression of SLPI was significantly correlated with histological differentiation, HPV infection, vascular invasion, lymph node metastasis, Silva classification, and FIGO stage of AC (P < 0.05).Conclusion: SLPI is low - expressed in cervical adenocarcinoma, which is closely related to the invasive biological and pathological characteristics. The low expression of SLPI is related to HPV infection, suggesting that SLPI may participate in the progression of cervical adenocarcinoma as a tumor - suppressor factor. The decrease in SLPI expression may indicate HPV infection. SLPI is expected to become a potential biomarker for the diagnosis, treatment, and prognosis of cervical adenocarcinoma.

  Key words: Secretory Leukocyte Protease Inhibitor; Adenocarcinoma in Situ；Adenocarcinoma in Situ of the Cervix; Cervical Adenocarcinoma; Human Papillomavirus

  提交时间：2025-05-14

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• 序号	提交日期	编号	操作
  1	2025-02-24	bmr.202505.00012V1	下载

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