通讯作者: 叶贝, yapapo991159@163.com

DOI：10.12201/bmr.202406.00030

The expression of CPNE1 and ZWILCH in the progression of lung adenocarcinoma and their correlation with prognosis

• 摘要：目的 分析CPNE1、ZWILCH在肺腺癌演进中的表达及与预后的相关性。方法 选取2020年1月～2021年3月于我院确诊的125例肺腺癌患者,经免疫组化检测癌组织、癌旁组织CPNE1、ZWILCH阳性率表达量,分析CPNE1、ZWILCH在肺腺癌演进中的表达差异。分析CPNE1、ZWILCH与肺腺癌患者预后的相关性,经Kaplan-Meier法绘制生存曲线,经Cox单因素、多因素分析影响肺腺癌患者预后的危险因素。结果 肺腺癌组织CPNE1、ZWILCH阳性率高于癌旁组织(P＜0.05)。Ⅲ～Ⅳ期、低分化、有胸膜侵犯、有脉管癌栓、有淋巴结转移肺腺癌患者CPNE1、ZWILCH阳性率升高(P＜0.05)。经分析CPNE1、ZWILCH阳性表达与肺腺癌患者预后的关系发现,CPNE1阳性组总生存率低于CPNE1阴性组(P＜0.05),ZWILCH阳性组总生存率低于ZWILCH阴性组(P＜0.05)。Cox多因素分析显示,Ⅲ～Ⅳ期、低分化、CPNE1阳性、ZWILCROC曲线发现,CPNE1联合ZWILCH预测肺腺癌患者预后的AUC为0.934,显著高于CPNE1、ZWILCH单独预测,预测灵敏度为91.09%、特异度为87.89%。结论 CPNE1、ZWILCH在肺腺癌演进中逐渐升高,两者阳性表达是肺腺癌患者预后生存的危险因素,或可作为辅助评估是肺腺癌患者预后的参考指标。

  关键词： 肺腺癌; CPNE1; ZWILCH; 演进; 预后

   

  Abstract: Objective Analyze the expression of CPNE1 and ZWILCH in the progression of lung adenocarcinoma and their correlation with prognosis. Methods A total of 125 lung adenocarcinoma patients diagnosed in our hospital from January 2020 to March 2021 were selected, the positive expression levels of CPNE1 and ZWILCH in cancer tissues and adjacent tissues were detected by immunohistochemistry, and the expression differences of CPNE1 and ZWILCH in the evolution of lung adenocarcinoma were analyzed. The correlation of CPNE1 and ZWILCH and the prognosis of patients with lung adenocarcinoma were analyzed, the survival curves were drawn by Kaplan-Meier method, and the risk factors affecting the prognosis of patients by Cox univariate and multivariate analysis. Results The positive rates of CPNE1 and ZWILCH in lung adenocarcinoma tissues were higher than those in paracancer tissues (P < 0.05). The positive rates of CPNE1 and ZWILCH were increased in patients with stage III-IV, poorly differentiated, pleural invasion, vascular cancer thrombus, and lymph node metastasis of lung adenocarcinoma (P<0.05). After analyzing the relationship between the positive expression of CPNE1 and ZWILCH and the prognosis of lung adenocarcinoma patients, it was found that the overall survival rate of the CPNE1 positive group was lower than that of the CPNE1 negative group (P<0.05), and the overall survival rate of the ZWILCH positive group was lower than that of the ZWILCH negative group (P<0.05). Cox multivariate analysis showed that stages III-IV, low differentiation, CPNE1 positive, and ZWILCROC curves showed that the AUC of CPNE1 combined with ZWILCH in predicting the prognosis of lung adenocarcinoma patients was 0.934, significantly higher than that of CPNE1 and ZWILCH alone, with a predictive sensitivity of 91.09% and specificity of 87.89%. Conclusion CPNE1 and ZWILCH gradually increase in the progression of lung adenocarcinoma, and their positive expression is a risk factor for the prognosis and survival of lung adenocarcinoma patients, or can be used as auxiliary evaluation indicators for the prognosis of lung adenocarcinoma patients.

  Key words: Lung adenocarcinoma; CPNE1; ZWILCH; Evolution; prognosis

  提交时间：2024-06-20

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• 序号	提交日期	编号	操作
  1	2024-04-22	bmr.202406.00030V1	下载

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