通讯作者: 徐芳芳, 1466266539@qq.com

DOI：10.12201/bmr.202510.00018

A Clinical Application Study of TCM-Based Fatigue Management Intervention Using the Transtheoretical Model in Patients Undergoing Hematopoietic Stem Cell Transplantation

• 摘要：摘要 目的 构建基于跨理论模型的造血干细胞移植患者中医干预疲乏管理方案并验证其方案的应用效果。方法 采用德尔菲法，历经两轮专家函询构建基于跨理论模型的造血干细胞移植患者中医干预疲乏管理方案。选取2024年1月至2024年12月在浙江中医药大学附属第一医院 / 浙江省中医院住院的造血干细胞移植患者70例，使用随机数字表发将其分为对照组（35例）和干预组（35例）。对照组给予病房常规护理，干预组在其基础上实施基于跨理论模型的造血干细胞移植患者中医干预疲乏管理方案，与干预前、干预90天后比较患者的疲乏程度、一般自我效能及生活质量。结果 本研究的干预组因疾病恶化退出1例。干预90天后，干预组的疲乏评分低于对照组(P<0.05)，一般自我效能及生活质量评分均高于对照组(P<0.05)。结论 基于跨理论模型的造血干细胞移植患者中医干预疲乏管理方案具有科学性与安全性，可减轻患者疲劳，提高其自我效能及改善生活质量。

  关键词： 造血干细胞移植；疲乏；跨理论模型；生活质量; ; ; 

   

  Abstract: AbstractObjective To develop a Traditional Chinese Medicine (TCM)–based fatigue management program for patients undergoing hematopoietic stem cell transplantation (HSCT) guided by the transtheoretical model of change (TTM), and to evaluate its practical effectiveness in improving patient outcomes. Methods The Delphi method was employed to design a structured fatigue management program based on the TTM. Two rounds of expert consultation were conducted to ensure scientific rigor and clinical applicability. From January to December 2024, a total of seventy HSCT inpatients admitted to the First Affiliated Hospital of Zhejiang Chinese Medical University / Zhejiang Provincial Hospital of Chinese Medicine of TCM were recruited. Participants were randomly assigned, using a random number table, to either a control group (n=35) or an intervention group (n=35). The control group received routine ward nursing, whereas the intervention group received the TCM fatigue management program based on the TTM in addition to standard care. The levels of fatigue, general self-efficacy, and quality of life were assessed before the intervention and again after 90 days of implementation using validated assessment tools. Results During the study, one participant in the intervention group withdrew due to disease progression. After 90 days of intervention, the fatigue score in the intervention group was significantly lower than that of the control group (P<0.05), while both general self-efficacy and quality of life scores were significantly higher than those observed in the control group (P<0.05). These results indicate that the proposed program effectively reduced fatigue symptoms and promoted positive psychological adaptation among HSCT patients. Conclusion The TCM fatigue management program for HSCT patients developed on the basis of the TTM demonstrated both scientific validity and safety. Its implementation effectively alleviated fatigue, enhanced patients’ self-efficacy, and improved overall quality of life.

  Key words: Hematopoietic stem cell transplantation; Fatigue; transtheore tical modelofchange; Quality of life

  提交时间：2025-10-12

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• 序号	提交日期	编号	操作
  1	2025-09-26	bmr.202510.00018V1	下载

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