通讯作者: 许景芬, 959727197@qq.com

DOI：10.12201/bmr.202506.00062

TyG Index and 2-Year Cognitive Function Changes in the Elderly: A Longitudinal StudyJingfen XU, Qian LI, Rongzhou YE,et al

• 摘要：目的：本研究旨在通过两年的随访，探讨老年甘油三酯葡萄糖指数（triglyceride glucose index, TyG）与认知功能变化的关系，为早期识别认知功能下降的高危人群提供依据。方法：纳入2022年9月至2022年12月于泉州市第一医院住院的101例≥60岁老年患者，基线及随访2年后采用蒙特利尔认知评估（montreal cognitive assessment, MOCA）量表评估认知功能；按基线TyG指数进行中分位分组，通过二元Logistic回归模型校正混杂因素，分析TyG指数与认知功能下降的关联性。结果：①Spearman相关性分析示TyG指数与认知功能变化值呈负相关（r=-0.243，P＜0.05）；②高TyG指数组认知功能下降发生率（43.1%）高于低TyG指数组（24.0%，P<0.05）；③调整混杂因素后，高TyG指数组发生认知功能下降的风险是低TyG指数组的2.971倍（P＜0.05）。结论：本研究老年住院患者TyG指数与2年认知功能变化相关，TyG指数或可作为认知功能减退早期预警的潜在生物标志物。

  关键词： 老年人; 甘油三酯葡萄糖指数; 蒙特利尔认知评估; 认知功能下降

   

  Abstract: Objective:This study was designed to explore the relationship between the triglyceride glucose index (TyG index) and cognitive function changes in elderly individuals over a two-year follow-up period, providing evidence for early identification of high-risk populations for cognitive decline. Methods: The study enrolled 101 elderly patients aged ≥60 years who were hospitalized at Quanzhou First Hospital between September 2022 and December 2022. Cognitive function was assessed using the Montreal Cognitive Assessment (MOCA) scale at baseline and after a 2-year follow-up period. Participants were divided into two groups based on median TyG index values at baseline. The association between TyG index and cognitive decline was analyzed using binary logistic regression models with adjustment for potential confounding factors.Results: ① Spearman correlation analysis revealed a negative correlation between the TyG index and changes in cognitive function (r = -0.243, P < 0.05); ② The high-TyG group showed a significantly higher incidence of cognitive decline (43.1%) compared to the low-TyG group (24.0%, P<0.05); ③ After adjusting for confounding factors, the risk of cognitive decline in the high TyG index group was 2.971 times higher than that in the low TyG index group (P < 0.05).Conclusions: This study indicate that the TyG index was associated with cognitive function changes over two years in elderly hospitalized patients. The TyG index may serve as a potential early-warning biomarker for cognitive decline.

  Key words: Elderly; Triglyceride glucose index; Montreal cognitive assessment; Cognitive decline

  提交时间：2025-06-24

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• 序号	提交日期	编号	操作
  1	2025-05-07	bmr.202506.00062V1	下载

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