通讯作者: 胡丹丹, dandanh2002@163.com

DOI：10.12201/bmr.202505.00021

Effect of Liuzijue Combined with External Treatment of Traditional Chinese Medicine on the efficacy and serum Inflammation levels in Stable COPD patients

• 摘要：摘要:目的 探讨六字诀联合中医外治法对慢性阻塞性肺病（chronic obstructive pulmonary disease，COPD）稳定期患者的疗效及炎症因子的影响。方法 将98例COPD稳定期患者随机均分为2组，对照组予常规西医治疗，治疗组在西医常规治疗的基础上予六字诀联合中医外治治疗，治疗持续8周。观察治疗前后2组患者中医证候积分、BODE指数及患者单核细胞趋化蛋白-1（monocyte chemoattractant protein-1，MCP-1）、白介素-35（interleukin-35，IL-35）和白介素-17（interleukin-17，IL-17）含量变化。结果 与治疗前相比，2组中医证候积分、BODE指数、MCP-1及IL-17水平均明显降低，IL-35水平明显升高，有统计学意义（P＜0.05）。2组治疗后，治疗组BODE指数、中医证候积分、MCP-1及IL-17水平均更低，IL-35水平更高，有统计学意义（P＜0.05）。结论 六字诀联合中医外治治疗可改善COPD稳定期患者BODE指数、中医证候积分，并降低促炎因子MCP-1及IL-17水平、提高抗炎因子IL-35水平。

  关键词： 慢性阻塞性肺病；六字诀；中医外治；炎症因子; ; ; 

   

  Abstract: Abstract: Objective: To investigate the clinical efficacy of the Liuzijue combined with external treatment of Traditional Chinese Medicine（TCM） on patients in stable Chronic Obstructive Pulmonary Disease（COPD）and its effects on inflammatory factors. Methods: A total of 98 patients in stable COPD were randomly assigned to either the treatment group or the control group. The control group was given standard western medicine treatment, and the treatment group was given external treatment of TCM combined with Liuzijue treatment on the basis of standard treatment. The treatment period lasted for 8 weeks. Outcome measures included TCM syndrome score, body-mass index，airflow obstruction，dyspnea，and exercise capacity index（BODE index）, and serum levels of monocyte chemoattractant protein-1（MCP-1）, interleukin-35（IL-35）, and interleukin-17（IL-17）before and after treatment. Results: Compared to baseline, both groups showed significant reductions in BODE index, TCM syndrome scores, MCP-1, and IL-17 levels, along with a significant increase in IL-35 levels (P < 0.05). The treatment group had lower BODE index, TCM syndrome scores, MCP-1, and IL-17 levels, and higher IL-35 levels compared to the control group, with statistically significant differences (P < 0.05). Conclusion: Liuzijue combined with TCM external treatment can improve the BODE index and TCM syndrome scores in patients with stable COPD, reduce pro-inflammatory factors MCP-1 and IL-17 levels, and increased levels of the anti-inflammatory factor IL-35.

  Key words: COPD; Liuzijue; Traditional Chinese Medicine external therapy; inflammation

  提交时间：2025-05-20

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• 序号	提交日期	编号	操作
  1	2025-01-08	bmr.202505.00021V1	下载

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