通讯作者: 杨晓彦, 1198492182@qq.com

DOI：10.12201/bmr.202505.00018

Predictive Value of First-Trimester Serological Markers PAPP-A and Free-hCGβ Combined with Gestational Weight Gain for Fetal Growth Restriction
????????????? Yang Wenying1? Yang Xiaoyan▲

• 摘要：中图分类号:R714:目的 分析孕早期血清学筛查指标妊娠相关血浆蛋白A(pregnancy associated plasma protein-A,PAPP-A)、游离β-人绒毛膜促性腺激素(free beta-human chorionic gonadotropin ,free-hCGβ)、孕期体重增长(Gestational weight gain,GWG)与胎儿生长受限(fetal growth restriction FGR )的关系,探索其对FGR的预测价值。方法 回顾性选取2021年1月1日至2024年1月于内蒙古自治区妇幼保健院规律孕检、孕早期于该院行血清学筛查、确诊并分娩的FGR患者作为病例组(n=426例),随机选择同期胎儿体重正常单胎妊娠孕妇作为对照组(n=520例)。采用SPSS24.0统计学软件分析两组孕妇基本资料、血清学筛查资料,并通过受试者工作特征(receiver operating characteristic ,ROC)曲线分析血清学筛查指标、GWG对FGR预测价值。结果(1)FGR组孕妇年龄31.49±2.29岁高于对照组30.89±2.20岁(P＜0.05),FGR组GWG、PAPP-A、free-hCGβ低于对照组(P＜0.05)(2)年龄、PAPP-A降低、free-hCGβ降低、GWG降低是FGR发生的独立危险因素(3)PAPP-A、free-hCGβ、年龄、GWG联合预测FGR的AUC为0.806(95%CI:0.778～0.834)。结论 FGR发生的影响因素包括:PAPP-A、free-hCGβ、年龄、GWG；PAPP-A、free-hCGβ、年龄、GWG联合预测FGR的价值较高。

  关键词： 胎儿生长受限; 妊娠相关血浆蛋白A; 孕期体重增长; 游离β-人绒毛膜促性腺激素

   

  Abstract: Objective To analyze the relationship between first-trimester serological screening markers pregnancy-associated plasma protein-A(PAPP-A), free beta-human chorionic gonadotropin (free-hCGβ), gestational weight gain (GWG), and fetal growth restriction (FGR), and to explore their predictive value for FGR. Method A retrospective study was conducted on 426 FGR patients (case group) who underwent regular prenatal care, first-trimester serological screening, and delivered at Inner Mongolia Maternal and Child Health Care Hospital from January 1, 2021, to January 2024. A control group of 520 normal-weight singleton pregnancies from the same period was randomly selected. SPSS 24.0 was used to analyze maternal characteristics and serological data. Receiver operating characteristic (ROC) curves were generated to evaluate the predictive value of serological markers and GWG for FGR. Results(1)Maternal age in the FGR group (31.49 ± 2.29 years) was higher than in the control group (30.89 ± 2.20 years,P< 0.05). GWG, PAPP-A, and free-hCGβ levels were significantly lower in the FGR group (P< 0.05).(2)Advanced maternal age, decreased PAPP-A, reduced free-hCGβ, and insufficient GWG were identified as independent risk factors for FGR.(3)The combined predictive model (PAPP-A, free-hCGβ, maternal age, and GWG) achieved an AUC of 0.806 (95% CI: 0.778–0.834) for FGR prediction. ConclusionKey factors influencing FGR include PAPP-A, free-hCGβ, maternal age, and GWG. The combination of these markers demonstrates high predictive value for FGR.

  Key words: Fetal growth restriction; Pregnancy-associated plasma protein-A; Gestational weight gain; Free beta-human chorionic gonadotropin

  提交时间：2025-05-19

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 曹丽敏, 张丽敏, 于欣, 王白石, 刘景利. 血清学指标与阴道彩超鉴别诊断早期异位妊娠、先兆流产的价值. 2024. doi: 10.12201/bmr.202408.00036

  李苍宁, 邱二娟. 健脾固胎方联合西医治疗对胎儿生长受限患者促血管生成素1、2及血同型半胱氨酸水平的影响. 2025. doi: 10.12201/bmr.202502.00038

  马家慧, 王忠. 心力衰竭患者血浆C1q/肿瘤坏死因子相关蛋白6、系统性炎症反应指数水平及临床意义. 2025. doi: 10.12201/bmr.202501.00060

  杨道玲, 周一波, 王戏丹, 陈静婉, 陈傅华, 陶肖樱. 胎儿心脏定量分析技术对妊娠期高血压患者胎儿早期心功能损害的评估. 2024. doi: 10.12201/bmr.202410.00076

  王灿, 李树民. 分泌型卷曲相关蛋白1与肺部疾病的研究进展. 2024. doi: 10.12201/bmr.202408.00013

  余梦诗, 毛倩, 罗青清. 胎膜早破并发组织学绒毛膜羊膜炎特征分析. 2025. doi: 10.12201/bmr.202504.00048

  陈颖, 韦红卫, 国林青, 覃钰芹, 唐丽春, 陈慧. 个体化营养干预联合一日门诊模式对妊娠期糖尿病孕妇妊娠结局的研究. 2025. doi: 10.12201/bmr.202502.00031

  陈庚, 蒋雯. 血清ALB、CRP、GLB对复发性糖尿病足溃疡的预测价值. 2024. doi: 10.12201/bmr.202410.00061

  陈辉, 刘若利, 朱雪莲, 金宣辰, 林文雅, 谢作流. 超声造影在睾丸肿块鉴别诊断中的临床应用价值. 2025. doi: 10.12201/bmr.202502.00061

  马亚鑫, 朱晓伟, 李淑琼, 李云翔, 孙永红. 儿童重症肺炎支原体肺炎早期预测的研究进展. 2025. doi: 10.12201/bmr.202504.00073

• 序号	提交日期	编号	操作
  1	2025-03-18	bmr.202505.00018V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论