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胎儿心脏定量分析技术对妊娠期高血压患者胎儿早期心功能损害的评估

通讯作者: 陶肖樱, 434599718@qq.com
DOI:10.12201/bmr.202410.00076
声明:预印本系统所发表的论文仅用于最新科研成果的交流与共享,未经同行评议,因此不建议直接应用于指导临床实践。

YANG Daoling, ZHOU Yibo, WANG Xidan, CHEN Jingwan, CHEN Fuhua, TAO XiaoyingFirst-author’s address: Department of Ultrasound Medicine, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, China

Corresponding author: taoxiaoying, 434599718@qq.com
  • 摘要:目的 探讨胎儿心脏定量分析技术(fetal HQ)评估妊娠期高血压患者胎儿心脏形态和功能的临床应用价值。 方法 选取2020年3月至2024年3月孕龄20-40周娠期高血压疾病孕妇85例作为观察组,根据孕妇的血压、尿蛋白及症状将观察组分为妊娠期高血压组(GH)35例,子痫前期轻度组(MPE)28例、子痫前期重度组(SPE)22例;另随机选择孕龄匹配的正常孕妇150例作为对照组(NOR);应用fetal HQ技术获取两组胎儿心脏形态指标和功能指标并进行统计分析。 结果 260例胎儿动态四腔心图像中,成功采集235例数据,成功率90%。同一患者胎儿心脏左右室FAC、Tei指数、GLS比较,左、右室GLS、FAC差异有统计学意义(P<0.05),右室GLS、FAC大于左室。各组患者形态指标GSI差异有统计学意义(P<0.05),SPE组患者胎儿心脏更圆。各组患者左右室FAC、Tei指数、GLS比较,右室GLS、右室Tei指数差异有统计学意义(P<0.05),S-PE组、M-PE组患者右室GLS绝对值低于NOR组,S-PE组患者右室Tei指数大于NOR组患者。 结论 Fetal HQ技术可快速、方便地定量评估胎儿心脏形态和功能。妊娠期高血压不仅使胎儿心脏形态发生变化,而且影响胎儿心脏功能,且对胎儿右心系统的影响大于左心。

    关键词: 妊娠期高血压;胎儿心脏定量分析技术;纵向应变;面积变化率;整体球形指数

     

    Abstract: Objective To explore the clinical application value of fetal quantitative analysis technology (fetal HQ) in evaluating the morphology and function of fetal heart in hypertensive disorders of pregnancy. Method A total of 85 women with gestational hypertension during the gestational age of 20-40 weeks from March 2020 to March 2024 had been selected as the experimental group. According to the blood pressure, urine protein, and symptoms of the pregnant women, the experimental group was divided into 35 cases of gestational hypertension group (GH), 28 cases of mild preeclampsia group (MPE), and 22 cases of severe preeclampsia group (SPE). Additionally, 150 normal pregnant women with matched gestational age were randomly selected as the control group (NOR). The fetal HQ technique was adopted to obtain cardiac morphological and functional indicators of both groups, and statistical analysis was conducted. Result Among 260 cases of fetal dynamic four-chamber heart images, data from 235 cases were successfully collected, with a success rate of 90%. Through comparison of the left and right ventricular FAC, Tei index, and GLS of the same patient’s fetal heart, there was a statistically significant difference (P<0.05) in GLS and FAC between the left and right ventricles, with the right ventricle having a higher GLS and FAC than the left ventricle. In addition, there was a statistically significant difference in GSI in each group (P<0.05). Patients in the SPE group had rounder fetal hearts. Besides, variance analysis was performed on left and right ventricular FAC, Tei index, and GLS for each group of patients. There was a statistically significant difference in right ventricular GLS and right ventricular Tei index (P<0.05). The absolute value of right ventricular GLS in the S-PE group and M-PE group was lower than that in the NOR group, while the right ventricular Tei index in the S-PE group was higher than that in the NOR group. Conclusions Fetal HQ technique provides quick and easy quantitative assessment of fetal heart shape and function. Gestational hypertension not only changes the fetal heart morphology, but also affects the fetal heart function, and the fetal right heart system is more affected than than the fetal left heart.

    Key words: Gestational hypertension; fetal heart quantification; longitudinal strain; fractional area change; global spherical index

    提交时间:2024-10-31

    版权声明:作者本人独立拥有该论文的版权,预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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  • 序号 提交日期 编号 操作
    1 2024-09-16

    bmr.202410.00076V1

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杨道玲, 周一波, 王戏丹, 陈静婉, 陈傅华, 陶肖樱. 胎儿心脏定量分析技术对妊娠期高血压患者胎儿早期心功能损害的评估. 2024. biomedRxiv.202410.00076

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