通讯作者: 范晓良, fanxiaoliang1022@163.com

DOI：10.12201/bmr.202504.00072

Analysis of medication rules of plaster method in

• 摘要：目的:基于中医传承辅助平台软件(V3.5),分析《理瀹骈文》中膏药方的用药规律,为临床用膏药方治疗疾病提供参考。方法:收集《理瀹骈文》中所用膏药方包括配合膏药使用的糁药、敷药等进行系统分析,将数据录入软件,采用软件集成的数据挖掘方法,通过方剂分析模块,对处方进行四气五味、性味归经、用药频次、组方规律分析,并通过复杂系统熵聚类的药物核心组合分析后演化出新处方；另外,对糁药方单独分析其糁药应用规律,并对膏药方中的收膏药物及十八反、十九畏药物进行分析。结果:在290首膏药方及糁药、敷药处方中,发现药物属性四气以温性、寒性为主,五味以辛、苦以及甘味为主,归经涵盖各经,运用聚类分析演化得到核心组合29个,新处方6个；糁药方中排名前3的药物分别是肉桂、黄连、丁香。158首膏药方中有153首为黑膏药,涉及十八反、十九畏药对使用共76首。结论:发现《理瀹骈文》中用药组合具有多样性和用药集中性,蕴含着内外治殊途同归的理念,可为临床在外治膏药的应用提供一些新的诊治思路。

  关键词： 理瀹骈文; 膏药; 用药规律; 数据挖掘

   

  Abstract: Objective: To analyze the medication rules of plaster prescriptions in Li Yue Pian Wen based on the traditional Chinese medicine inheritance assistance platform software (V3.5)，and provide a reference for the clinical use of plaster prescriptions to treat diseases. Methods: Collect the plaster prescriptions used in Li Yue Pian Wen, including the scattered drugs and application drugs used in conjunction with plasters for systematic analysis. Enter the data into the software and use the integrated data mining method.. Through the prescription analysis module, analyze the four qi and five flavors, nature and meridian tropism, medication frequency, and prescription combination rules of prescriptions. After analyzing the core drug combinations through complex system entropy clustering, new prescriptions are evolved. In addition, analyze the application rules of scattered drugs in scattered drug prescriptions separately, and analyze the plaster-condensing drugs and drugs involved in the eighteen incompatible and nineteen mutual restraint pairs in plaster prescriptions. Results: Among 290 plaster prescriptions and prescriptions for scattered drugs and application drugs, it was found that the four qi of drug properties were mainly warm and cold, the five flavors were mainly pungent, bitter, and sweet, and the meridian tropisms covered all meridians. Through cluster analysis, 29 core combinations and 6 new prescriptions are evolved. The top three drugs in scattered drug prescriptions are CortexCinnamomi, CoptidisRhizoma, and Caryophylli Flos. Among 158 plaster prescriptions, 153 were black plasters, and a total of 76 prescriptions involved the use of drug pairs in the eighteen incompatible and nineteen mutual restraint pairs. Conclusion: It was found that the medication combinations in Li Yue Pian Wen had diversity and concentration in medication, and contained the concept that internal and external treatments lead to the same goal. It can provided some new diagnostic and treatment ideas for the clinical application of external treatment plasters.

  Key words: Li Yue Pian Wen; plasters; medication rules; data mining

  提交时间：2025-04-27

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• 序号	提交日期	编号	操作
  1	2025-04-09	bmr.202504.00072V1	下载

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